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Dietary Intervention for Migraine Relief

Diet-Based Treatment for Migraine Relief

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 75 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: Urine samples, Questionnaires, MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "All participants will complete questionnaires, provide blood and urine samples, and undergo in-person assessments at the end of each study phase."
  • "A subset of participants will also undergo Magnetic Resonance Imaging (MRI) scans."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether a low-glutamate diet can reduce migraine days and make attacks shorter and less severe. It is for adults ages 18–75 who have had a migraine diagnosis for at least 6 months. Researchers will compare the diet with participants' usual diets and look for blood changes linked to migraine improvement.

The goal of this clinical trial is to evaluate whether a low-glutamate diet can improve migraine symptoms in adults with migraine and to explore possible biological changes associated with dietary improvement. The study focuses on whether reducing dietary glutamate intake may influence processes involved in migraine, such as brain excitation, inflammation, and oxidative stress. The main questions this study aims to answer are: Does following a low-glutamate diet reduce the number of migraine days and the severity and duration of migraine attacks, and improve quality of life? Are improvements in migraine symptoms associated with changes in blood-based biological markers related to migraine activity? Researchers will compare participants assigned to the low-glutamate diet with participants assigned to a wait-list control group to evaluate differences in migraine outcomes and related biological measures. Participants will: Complete a baseline run-in period while tracking headaches using a daily migraine diary Either follow a low-glutamate dietary intervention or continue their usual diet as part of a wait-list control Complete standardized questionnaires related to migraine symptoms and quality of life Provide blood samples for laboratory analyses Undergo neuroimaging assessments (for a subset of participants)

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Men and women of all races and ethnic backgrounds may join.
  • You must be 18–75 years old.
  • You must have a documented migraine diagnosis for at least 6 months, with 8 headache days and 4 migraine days per month.
  • Your migraines must have started before age 50.
  • Your medicines must have stayed the same for at least 1 month before joining.
  • You must be willing to keep your medicines the same during the study.
  • You must be willing to stop taking supplements during the study.
  • Women who can become pregnant must be willing to use birth control during the study.

Who can't join

  • You are pregnant, plan to become pregnant during the study, or are breastfeeding.
  • You take medicines that affect glutamate or GABA, chemicals that help brain cells send signals, unless you stop them with a doctor's guidance.
  • You use migraine prevention shots given every 3 months.
  • You are unwilling to change your diet or stop using alcohol and marijuana during the study.
  • You have had a substance use disorder, meaning problems controlling alcohol or drug use, within the past year.
  • You have been diagnosed with a seizure disorder.
  • You have severe asthma that has required a hospital stay.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Men and women of all races and ethnicities * Age 18-75 years * Documented diagnosis of chronic or episodic migraine for at least 6 months, based on International Classification of Headache Disorders, 3rd edition (ICHD-III) criteria, defined as: * 8 headache days per month, and * 4 migraine days per month * Migraine onset before age 50 * On a stable medication regimen for at least 1 month prior to enrollment * Willing to maintain stable medications throughout the study * Willing to discontinue supplements during the study period * Women of childbearing potential must be willing to use birth control during the study timeframe Exclusion Criteria: * Current pregnancy, plans to become pregnant during the study timeframe, or current breastfeeding * Current use of medications affecting glutamatergic or gamma-Aminobutyric Acid (GABA) neurotransmission (unless discontinued under physician guidance) * Current use of quarterly injectable migraine preventive medications * Unwillingness to modify dietary intake or to stop alcohol and marijuana use during the study * Substance use disorder within the past year * Diagnosed seizure disorder * Severe asthma requiring past hospitalization

Study sites (1)

DC