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Zesty Exercise System for Therapeutic Engagement

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
40 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Time periods mentioned: 3 weeks

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Participants will complete robot-guided exercise three times per week for three weeks."
  • "Participants will complete exercise sessions three times per week for three weeks."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests robot-guided exercise with the ZEST-E system for older adults with mild to moderate Parkinson’s disease. People will exercise three times a week for three weeks, with sessions watched in person or from a distance. The study will check safety, comfort, how well people stick with the program, and changes in movement and lower-body strength.

This study will evaluate exercise delivered through the Zesty Exercise System for Therapeutic Engagement (ZEST-E) for people with Parkinson's disease when sessions are monitored either in person or remotely. Participants will complete robot-guided exercise three times per week for three weeks. The study will assess feasibility, retention, safety, acceptability, and tolerability of remotely monitored ZEST-E and will measure changes in functional performance using the Standing Forward Reach test and the 30-Second Chair Stand test. These outcomes reflect range of motion and lower-body strength targeted by the exercise program.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Older adults with mild to moderate Parkinson’s disease.

Who can't join

  • Under age 40.
  • A sudden illness that needs hospital care, or inability to complete study activities.
  • Uncontrolled heart failure, or a stroke in the past three years.
  • Health problems that prevent participation, such as severe arthritis, trouble moving, uncontrolled high blood pressure or diabetes, kidney failure, or chest pain with activity.
  • Use of medicines that could harm thinking, such as antipsychotics, opioid pain medicines, stimulants, or chemotherapy.
  • A disorder that affects your sense of reality; or a substance use disorder, major depression, or generalized anxiety disorder within six months of the evaluation.
  • Other brain or nerve conditions that could affect study results, such as certain active infections, seizures, brain tumors, a head injury causing more than 30 minutes of unconsciousness, or lasting brain or mental health effects from a stroke.
  • A Hoehn and Yahr Parkinson’s stage above 3, or a MoCA thinking and memory test score below 17.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: -Older adults with mild to moderate PD. Exclusion Criteria: * Acute medical illness requiring hospitalization; * Under 40 years old; * Uncontrolled congestive heart failure; * History of stroke in the past three years; * Inability to perform study procedures; * Medical or physical conditions that would preclude participation (e.g., severe arthritis or mobility problems, uncontrolled hypertension or diabetes, renal failure, history of angina with activity); * On medications that could adversely affect cognition, e.g.: antipsychotics, opioids, stimulants, chemotherapy; * Psychotic disorders; * Confounding neurologic conditions (e.g., active central nervous system opportunistic infections, seizure disorders, head injury with loss of consciousness \>30 minutes, intracranial neoplasms, stroke with neurological or neuropsychiatric sequelae); * Substance Use Disorder, Major Depressive and Generalized Anxiety Disorders within six months of evaluation; * Hohn \& Yahr \> 3 * MoCA \<17

Study sites (1)

GA