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GCC 2546- Motion Management

Combining 4D MRI and 4DCT for Personalized Volumetric Motion Monitoring in Lung Radiation Therapy

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: MRI scans, X-rays

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "This will be assessed through a four-dimensional magnetic resonance imaging (MRI) scan before starting your radiation treatment and x-ray fluoroscopy images that are taken during radiation"
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests a way to track lung tumors and nearby organs as patients breathe during radiation treatment. It is for adults with stage II–IIIb non-small cell lung cancer. The study uses an MRI scan before treatment and moving x-ray images during treatment.

The purpose of this study is to assess a real time motion tracking of lung tumors and important organs next to the tumor while breathing during a participant's radiation treatment. This will be assessed through a four-dimensional magnetic resonance imaging (MRI) scan before starting your radiation treatment and x-ray fluoroscopy images that are taken during radiation

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Age 18 or older, with stage II–IIIb non-small cell lung cancer confirmed by a tissue test.
  • Will receive photon radiation from a machine outside the body to treat the cancer, with or without medicines such as chemotherapy or immune therapy.
  • Any number of radiation sessions and any number or location of tumors are allowed.
  • Have an ECOG activity score of 0–3, meaning you may need help caring for yourself but are not completely disabled.
  • Can have MRI scans.
  • Have signed a consent form and agreed to the study steps.

Who can't join

  • Cannot have an MRI because of certain objects, implants, or devices in or on the body. Examples include some ear or eye implants, clips on blood vessels, heart devices or wires, tissue expanders, recent stents, penile implants, medicine patches, or artificial limbs.
  • Have claustrophobia, or fear of small, closed spaces, that prevents an MRI.
  • Are pregnant or trying to get pregnant.
  • Have pain when lying on your back, or cannot raise your arm above your head while lying on your back.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: 1. Adult (≥18 years) patients (both sexes) with histologically diagnosed Stage II-IIIb NSCLC 2. Patients to be treated with definitive external beam photon radiotherapy with or without systemic therapy (e.g., chemotherapy, immunotherapy). 3. No restrictions on number radiotherapy fractions, or location/number of lesions 4. ECOG performance status ≤ 3 5. Ability to undergo MRI scans 6. Patient has signed informed consent document and agreed to study procedures Exclusion Criteria: 1. Pre-existing contraindications for MRI, such as any MRI-conditional or MRI-unsafe foreign objects within the body, non-removable ear cochlear or eye implant, aneurysm clip, cardiac pacemaker/wires, internal defibrillator, tissue expander, recent stent placement, penile prosthesis, medication patch, artificial limb, pregnancy, and claustrophobia 2. Women who are pregnant or trying to get pregnant (self-reported) 3. Pain in supine position or inability to raise arm above head in supine position

Study sites (1)

MD