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Neurophysiology of Reward Signaling in Parkinson's Disease

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
40 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at brain activity linked to risk taking and seeking rewards in Parkinson's disease. It is for adults age 40 or older with Parkinson's disease or another movement disorder who are scheduled for deep brain stimulation surgery. Researchers will record brain activity during surgery to study symptoms that do not involve movement.

The goal of this study is to learn more about the brain activity underlying Parkinson's disease risk taking and reward seeking behaviors. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Scheduled for deep brain stimulation surgery at Vanderbilt University Medical Center with local anesthesia, which numbs the surgery area.
  • The planned path of the electrode, a wire used in surgery, must touch a brain area called the caudate.
  • Age 40 or older.
  • Have Parkinson's disease or another movement disorder.
  • Able to take part in tests during surgery.
  • Speak English.

Who can't join

  • Younger than 40.
  • Unable to take part in tests during surgery, such as having trouble understanding instructions or following directions.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center * Planned clinical electrode trajectory that contacts caudate * Age greater than or equal to 40 * Diagnosis of Parkinson's disease or other movement disorder * Able to participate in intraoperative testing * English speaking Exclusion Criteria: * Age less than 40 * Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)

Study sites (1)

TN