RightFit
RecruitingPhase 4

Ventilation and Perfusion in Asthmatics

Ventilation and Perfusion in Individuals With Asthma

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 75 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests how an inhaled steroid and a fast-acting inhaled medicine affect airflow and blood flow in different parts of the lungs. It uses lung images to study these changes in adults ages 18–75 with asthma.

Assess regional changes to perfusion and ventilation from inhaled corticosteroid (ICS) and Fast-acting beta-antagonist (FABA) among adult asthmatics using radiographically derived estimates of regional ventilation (V-distribution), ventilation defect percentage (VDP), and ventilation heterogeneity (VH).

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • A doctor has diagnosed you with asthma.
  • A breathing test shows you blow out less than 80% of the expected air in one second, with a 10% improvement after medicine that opens your airways.
  • You are 18–75 years old.
  • You use a long-term asthma control medicine that includes an inhaled steroid, with no dose change for at least 3 months before joining.

Who can't join

  • You smoke cigarettes now or have smoked more than 10 pack-years. One pack-year means smoking one pack a day for one year.
  • You currently vape nicotine.
  • You are pregnant or breastfeeding.
  • You had an infection in your lungs or airways within 4 weeks before the planned study date.
  • Your breathing test result for air blown out in one second (FEV1) is below 50%.
  • You cannot tolerate inhaled steroids or fast-acting beta agonists, medicines that open your airways.
  • You take beta-blockers, medicines often used for heart problems or high blood pressure.
  • Within 30 days before the planned study visit, you used steroids that treat the whole body or oral methyl-xanthines, a type of breathing medicine taken by mouth.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Physician diagnosis of asthma * Baseline Forced Expiratory Volume in 1 Second (FEV1) \< 80% of predicted, with reversibility (10%) on post-bronchodilator spirometry * Adults, 18-75 years of age * Long-term inhaled controller medication consisting of or including an Inhaled corticosteroids (ICS) at a steady dose for at least 3 months before enrollment Exclusion Criteria: * Current cigarette smoking or a past history of \>10 pack-year smoking * Current nicotine vaping * Pregnant and breast-feeding women * Respiratory infection within 4 weeks of proposed study date * Forced Expiratory Volume in 1 Second (FEV1) \< 50% * Inhaled corticosteroids (ICS)/fast-acting beta agonist (FABA) intolerance * Use of beta-blockers * Use of systemic glucocorticosteroids or oral methyl-xanthines within 30 days of planned study visit.

Study sites (1)

FL