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Exercise With and Without Cognitive Training

The Effect of Exercise With and Without Cognitive Training on Gait in Older Veterans With Multiple Sclerosis

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
55 Years to 85 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Time periods mentioned: 12 months

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Following the intervention, the investigators will track falls for 12 months with an Apple watch and fall calendars."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests walking and strength training with or without computer-based thinking exercises in older U.S. Veterans with multiple sclerosis (MS). Training lasts 10 weeks, followed by 12 months of fall tracking using sensors and calendars. Researchers will study walking, thinking, falls, and signs of inflammation linked to the nervous system.

This proposal aims to conduct a 10-week randomized controlled trial comparing walking and resistance training with and without computerized cognitive training in older Veterans with Multiple Sclerosis, followed by 12 months of fall tracking with sensors and fall calendars. The primary objectives of this proposed CDA2 are to provide critical preliminary data on 1) the feasibility of conducting a 10-week RCT, 2) preliminary treatment effects on gait, cognition, and falls, and 3) neuroinflammatory biomarkers. Dr. Katherine Hsieh will receive hands-on training in the design and conduct of clinical trials (Dr. Hackney), mechanisms underlying physical activity, cognitive rehabilitation, and falls (Drs. Twamley, Hackney, \& Kesar), fall detection technology (Prof. Sanford), and clinical problems faced by MS participants (Dr. Backus) to achieve her long-term career goal of becoming an independent falls prevention investigator.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Are a U.S. Veteran.
  • Have multiple sclerosis (MS).
  • Have had no MS flare-up in the past 30 days.
  • Can stand without help for at least 1 minute.
  • Have a score below 6.5 on the Expanded Disability Status Scale, which measures disability from MS.
  • Can speak and understand English.

Who can't join

  • Have a brain or nerve disorder other than MS.
  • Score below 20 on the Modified Telephone Interview for Cognitive Status, a phone test of memory and thinking.
  • Are currently in another study of exercise or training to improve thinking skills.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * US Veteran * Diagnosis of Multiple Sclerosis * Relapse free in the last 30 days * Capable of standing unaided for at least 1 minute * Expanded Disability Status Scale \<6.5 * Ability to speak and understand English Exclusion Criteria: * Any neurological disorder other than MS * Modified Telephone Interview for Cognitive Status \<20 * Current participation in an exercise or cognitive rehabilitation study

Study sites (1)

GA