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Exploring the Feasibility of an Exercise and Noninvasive Brain Stimulation Intervention in Breast Cancer Survivors

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether a 4-week program of exercise and gentle electrical brain stimulation is safe and practical. It is for breast cancer survivors who report thinking or memory problems after cancer treatment. Researchers will compare exercise plus real brain stimulation with exercise plus fake stimulation, and check changes in thinking and physical skills.

The purpose of this study is to assess the feasibility of a 4-week intervention combining exercise and transcranial alternating current stimulation (Ex+tACS) in breast cancer survivors who report experiencing cancer-related cognitive impairment. Feasibility will be assessed by measuring participant retention, adherence, satisfaction with the intervention, and safety. The researchers will also examine pre-to-post intervention changes in attention, executive function, working memory, perceived cognitive function, and physical function before, after, and four weeks post intervention completion in the Ex+tACS group compared to a control group who will receive exercise and a placebo tACS condition (CON).

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Age 18 or older.
  • Had stage 0–3 breast cancer that had not spread to distant parts of the body.
  • Finished main breast cancer treatment, such as surgery, chemotherapy, or radiation, at least 3 months ago.
  • Report thinking or memory problems after cancer treatment.

Who can't join

  • Currently do at least 60 minutes a week of aerobic exercise, such as brisk walking.
  • Have a condition that makes exercise unsafe under American College of Sports Medicine guidelines.
  • Have a serious medical illness or metal implants.
  • Have had a brain injury, epilepsy or seizures, or surgery on the head or spinal cord.
  • Have skin problems on the forehead where the brain stimulation pads would go.
  • Have heart or blood vessel disease that is not controlled.
  • Have cancer that has spread to distant parts of the body, or were diagnosed with another cancer within the past 5 years. Melanoma, a type of skin cancer, does not count as another cancer for this rule.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Breast cancer survivors (≥18 years) will be eligible to participate if the following inclusion criteria is met: * Diagnosed non-metastatic breast cancer (stages 0-3) * Completed primary breast cancer treatment (surgery, chemotherapy, radiation) for at least 3 months * Self-reported cognitive impairment after cancer treatment Exclusion Criteria: * Current participation in aerobic exercise for ≥60 min/wk * Contraindication or impairment that precludes the potential participant from exercise as defined by the American College of Sports Medicine * The presence of serious medical illnesses, metal implants, previous brain trauma, epilepsy or history of seizures, previous surgery to the head or spinal cord, or skin problems at the forehead area where the tACS electrodes will be applied * Uncontrolled cardiovascular disease * Functional impairments or physical condition that would make exercise unsafe * Metastatic cancer or diagnosis of a different cancer (excluding melanoma) within the past 5 years * Contraindication to exercise a defined by the American College of Sports Medicine

Study sites (1)

FL