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LEGACY: Lung Cancer Screening in Individuals With a Lung Cancer Family History-Protocol B

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not stated
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether a computer tool called Sybil can predict future lung cancer risk using chest CT scans, which take detailed pictures inside the chest. It is for adults who have a family history of lung cancer.

This research is being done to determine if an image-based deep learning model (Sybil) can accurately predict the likelihood of future lung cancer based on chest computed tomography (CT) imaging from individuals with a family history of lung cancer.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are age 18 or older.
  • You have at least 1 parent, sibling, or child with lung cancer, OR at least 2 relatives from this group with lung cancer: grandparents, blood-related aunts or uncles, grandchildren, blood-related nieces or nephews, or half-siblings.
  • Your relatives' lung cancer must be either non-small cell or small cell lung cancer, the two main types.
  • You are willing to share pictures from at least 1 past chest CT scan, if available.

Who can't join

    Simplified for readability. The official criteria below are what the study team uses.

    Official eligibility criteria

    Inclusion Criteria: * ≥18 years of age * Positive family history of lung cancer (defined as): * Has ≥1 first-degree relative OR * Has ≥2 second-degree relatives with a diagnosis of non-small cell lung cancer or small cell lung cancer (NB: a first-degree relative = parent, sibling, or child, a second-degree relative = grandparent, blood-related aunt or uncle, grandchild, blood-related niece or nephew, half-sibling) * Willing to provide images from at least one previously obtained CT Chest scan, if available. Exclusion Criteria: \- None

    Study sites (1)

    MA