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Optimizing CBSST With Executive Function Training for Schizophrenia (R33)

Optimizing Cognitive Behavioral Social Skills Training With Executive Function Training for Older Adults With Schizophrenia

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
60 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Time periods mentioned: 20 weeks

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "In an open trial, 54 participants with schizophrenia or schizoaffective disorder age 60 or older were enrolled to receive E-CBSST for 20 weeks."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests E-CBSST, which combines training in thinking and planning with training in coping and social skills. It is for adults age 60 or older with schizophrenia or schizoaffective disorder. The study compares this training with supportive contact to see if it helps people learn skills and do better in daily life.

This randomized controlled clinical trial will test a blended intervention that combines Executive Function Training with Cognitive-Behavioral Skills Training (E-CBSST). E-CBSST will be delivered to adults with late-life schizophrenia to determine if it increases Cognitive Behavioral Social Skills Training skills learning more than a supportive contact control condition and leads to improved functioning.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Choose to join after learning about the study and giving consent.
  • Be age 60 or older.
  • Have schizophrenia or schizoaffective disorder, confirmed by a study interview. Schizoaffective disorder includes symptoms of schizophrenia and mood problems.
  • Have no mental health hospital stays in the 3 months before the assessment.
  • Have no dose changes in medicine for psychosis in the 4 weeks before the starting assessment.
  • Be judged mentally and physically stable by a study researcher.
  • Be willing and able to speak English.
  • Be able to read and have a conversation, using vision or hearing aids if needed.

Who can't join

  • Have a thinking or memory disorder, a brain or nerve disorder, or another medical condition that affects your ability to take part in the training.
  • Have bipolar disorder or a current episode of major depression.
  • Have had substance abuse or dependence in the 6 months before the starting assessment, except for caffeine or nicotine.
  • Have received electroconvulsive therapy (ECT), a treatment that uses electrical pulses to stimulate the brain, in the 6 months before the starting assessment.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: 1. Voluntary informed consent to participate; 2. Age 60 years or older; 3. DSM-5 diagnosis of schizophrenia or schizoaffective disorder based on the SCID; 4. Be clinically stable as operationalized by (1) not having been admitted to a psychiatric hospital within the three months prior to assessment, (2) having had no change in antipsychotic medication dosage within four weeks prior to the baseline assessment, and (3) and ascertained to be clinically and medically stable by one the study investigators; 5. Be willing and able to speak English; 6. Be able to read and converse (with corrected vision or hearing if needed). Exclusion Criteria: 1. Meets criteria for a cognitive disorder or for a neurological or other medical disorder affecting the ability to participate in Executive Function Training or CBSST; 2. Meets diagnostic criteria for bipolar disorder, current major depressive episode, or substance abuse or dependence within the six months prior to the baseline assessment except for caffeine or nicotine; 3. Received electroconvulsive therapy within six months of the baseline assessment.

Study sites (2)

CA

TX