Moving Yourself in Space and Time: MYSTIC
Moving Yourself in Space and Time Identifying Spatial and Temporal Components of Complex Rhythmic Movement Training for People With Parkinson's Disease and Cognitive Impairment
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 18 Years to 79 Years
- Sex
- All sexes
- Healthy volunteers
- Accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
In plain language
This study tests whether a new stepping therapy helps people with Parkinson’s disease and how they learn steps and rhythms set to music. It compares people with Parkinson’s, people with mild memory or thinking problems, and people with neither condition. The study includes adults ages 18–35 and 50–79 who meet the rules for their group.
This study is being done to answer the question: Do people with Parkinson's benefit from a new stepping therapy, and how do people with Parkinson's best learn new steps and rhythms set to music? Researchers will also compare individuals with Parkinson's Disease with people with Mild Cognitive Impairment, and with people with neither of these conditions. The purpose of this study is to identify principles of human-music interactions to establish underlying guiding theories for application to music-based rehabilitation for older populations with neurodegenerative disease, leading to more refined and targeted music-based rhythmic movement therapies.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Who can join
- Adults ages 18–35: a score of 26–30 on the Montreal Cognitive Assessment (MoCA), a test of memory and thinking.
- Adults ages 50–79: with or without mild cognitive impairment, which means mild memory or thinking problems.
- Adults ages 50–79 with Parkinson’s: must be able to make their own decisions.
- Adults ages 50–79: less than 150 minutes of moderate exercise or 75 minutes of vigorous exercise per week.
Who can't join
- A current illness that needs hospital care, uncontrolled heart failure, or a stroke in the past 3 years.
- Unable to do study tasks, or health problems that prevent joining, such as severe arthritis, trouble moving, uncontrolled high blood pressure or diabetes, kidney failure, or chest pain with activity.
- Medicines that could harm thinking, such as antipsychotics, opioids, stimulants, chemotherapy, or medicines for multiple sclerosis. For some memory medicines, joining may be delayed until the dose has stayed the same for at least 3 months.
- Psychotic disorders, which can make it hard to tell what is real.
- Other brain or nerve conditions that could affect results, such as certain active brain or spinal cord infections, seizures, brain tumors, a head injury causing more than 30 minutes of unconsciousness, or lasting problems from a stroke.
- A substance use disorder, major depression, or generalized anxiety disorder within 6 months of the study evaluation.
- Unable to give informed consent, meaning you cannot understand the study and agree to join.
Simplified for readability. The official criteria below are what the study team uses.
Official eligibility criteria
Inclusion Criteria for Young adults and adults with normal cognition (NC): * 18 to 35 Years old * Montreal Cognitive Assessment (MoCA) score of 26 to 30 Inclusion Criteria for Older Adults: * 50 to 79 with or without MCI * 50 to 79 years old with Parkinson's disease (PD), who do NOT have impaired decision-making capacity * Participants who achieve less than 150 minutes moderate or 75 minutes vigorous aerobic activity per week (as per the US Department of Health and Human Services (HHS)), Exclusion Criteria for all groups: * Acute medical illness requiring hospitalization; * Uncontrolled congestive heart failure; * History of stroke in the past three years; * Inability to perform study procedures; * Medical or physical conditions that would preclude participation (e.g., severe arthritis or mobility problems, uncontrolled hypertension or diabetes, renal failure, history of angina with activity); * On medications that could adversely affect cognition, e.g., antipsychotics, opioids, stimulants, chemotherapy, and neurologic prescriptions to treat Multiple Sclerosis. When applicable, enrollment will be delayed until dosages are stable on e.g., Aricept, Namenda, anticholinesterase inhibitors, for at least 3 months * Psychotic disorders * Confounding neurologic conditions \[e.g., active central nervous system (CNS) opportunistic infections, seizure disorders, head injury with loss of consciousness \>30 minutes, intracranial neoplasms, stroke with neurological or neuropsychiatric sequelae\] * Substance Use Disorder, Major Depressive Disorder, and Generalized Anxiety Disorder within six months of evaluation. * Inability to provide informed consent
Study sites (1)
GA
- Emory University, Executive Park, Wesley Woods · Atlanta, GA 30329Madeleine E. Hackney, PhD · Study contact · mehackn@emory.eduMore trials in Atlanta