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A Pilot Study Assessing Myokines During an EXErcise Regimen After Treatment for Breast Cancer

Myo-EXERTBC: A Pilot Study Assessing Myokines During an EXErcise Regimen After Treatment for Breast Cancer

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
20 Years to 89 Years
Sex
Female only
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This small study looks at how different exercise plans change the production of myokines, substances made by muscles. It is for women who have been treated for breast cancer and have experience with guided strength training.

In this pilot study, the investigators will assess the changes in myokine production based on several different exercise regimens.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Women ages 20–89.
  • Have been prescribed exercise as part of their usual care.
  • Have breast cancer confirmed by a biopsy (a tissue sample): DCIS, cancer inside the milk ducts, or invasive cancer, which has spread into nearby breast tissue.
  • Have received breast cancer treatment, such as surgery, radiation, chemotherapy, immune treatment, or hormone treatment. Current chemotherapy is not allowed, but immune treatment or targeted cancer drugs are allowed.
  • Have more than 3 months of strength training with expert guidance at the Allegheny Health Network Exercise Oncology Center.

Who can't join

  • Are currently getting cytotoxic chemotherapy, drugs that kill cancer cells, for breast cancer.
  • Cannot safely take part in group strength training, as judged by the lead study doctor.
  • Have severe arthritis or a joint, heart, blood vessel, muscle, or bone condition that the lead study doctor believes makes strength training unsafe.
  • Are pregnant.
  • Are male.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: 1. Age 20-89 years 2. Women prescribed exercise as a SOC 3. Women with a biopsy proven diagnosis of ductal carcinoma in situ (DCIS) or invasive carcinoma of the breast 4. Women must have undergone treatment for breast cancer, including one or more of the following: surgery, radiation therapy, chemotherapy, immunotherapy, or hormonal therapy. Women undergoing active chemotherapy are not allowed on study. Immunotherapy or targeted agent usage is allowed. 5. Women with \> 3 months of resistance training experience under expert guidance at the Allegheny Health Network Exercise Oncology Center Exclusion Criteria: 1. Any current treatment with cytotoxic chemotherapy for breast cancer 2. Inability to safely engage in group sessions of resistance training as deemed by study PI 3. Severe arthritic, joint, cardiovascular, or musculoskeletal condition deemed by PI to be unsafe to engage in resistance training 4. Pregnant women 5. Males

Study sites (2)

PA