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Combating Age-related Failure of Myelination in Multiple Sclerosis: An Exploratory Study

Combating Age-related Failure of Myelination in Multiple Sclerosis: an Exploratory Study

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
50 Years to 70 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: MRI scans, Questionnaires

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Participants will undergo magnetic resonance imaging (MRI) scans to measure myelin throughout the central nervous system and will wear wrist-worn activity trackers to assess physical activity over time."
  • "At both baseline and 6 months, MRI and clinical assessments will be obtained, and chart review will be performed."
  • "Participants will wear a wrist-worn physical activity monitor and answer monthly questionnaires (assessed via REDCap survey) throughout the study period."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study follows adults ages 50 to 70 with multiple sclerosis (MS) to see if physical activity and other lifestyle habits are linked to changes in myelin, the protective coating around nerves. Participants will have MRI scans to measure myelin and wear wrist activity trackers over time.

This observational, longitudinal study will examine whether physical activity and other potentially modifiable lifestyle factors are associated with changes in myelin, the protective coating around nerve fibers, in older adults with multiple sclerosis (MS). Participants will undergo magnetic resonance imaging (MRI) scans to measure myelin throughout the central nervous system and will wear wrist-worn activity trackers to assess physical activity over time.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Have multiple sclerosis (MS).
  • Can walk 500 meters without help or a walking aid.
  • Have had MS for more than 10 years.
  • Are 50 to 70 years old.
  • Can read, speak, and understand English.

Who can't join

  • Have another disease affecting the nervous system that could make results hard to understand, such as stroke, MOGAD, NMO, or sarcoidosis.
  • Cannot complete study tasks, including MRI scans at BMIC and using a Fitbit linked to a smartphone.
  • Are currently in another clinical trial testing repair of myelin, the protective coating around nerves.
  • Are pregnant. Staff will ask about pregnancy at screening and before each MRI, but will not provide pregnancy tests.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Diagnosis of multiple sclerosis * Independent with ambulation (able to walk 500m without aid) * Disease duration \>10 years * Age 50 to 70 years (inclusive) * Be able to read, speak, and understand English Exclusion Criteria: * Diagnosis of other neurologic disease that would interfere with interpretation such as stroke, myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), neuromyelitis optica (NMO), and sarcoidosis. * Inability to complete study procedures (including obtaining MRI at BMIC and using Fitbit connected to smartphone) * Currently participating in another clinical trial on remyelination * Pregnancy. (Pregnancy status will be asked at screening and before each MRI. Pregnancy testing will not be offered as part of this study.)

Study sites (1)

WA