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Assessing Treatment With High-phenolic EVOO Supplements for Neurovascular Activity

Dietary Supplementation With EVOO Phenolics Prevents MCI Progression to Alzheimer's Disease

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
50 Years to 70 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether a supplement with phenolics, compounds found in extra-virgin olive oil, can improve memory in people with mild cognitive impairment (mild memory or thinking problems). It also looks at blood vessel function and other signs of these problems in the body. Participants take the supplement or a placebo (a look-alike with no EVOO phenolics) daily for 6 months and visit the study site for screening and tests.

The goal of this clinical trial is to determine whether the extra-virgin olive oil (EVOO) phenolic dietary supplement can improve memory function and modulate biomarkers among individuals with mild cognitive impairment (MCI). The main questions it aims to answer are: * Does dietary supplementation with EVOO phenolics improve cognitive function? * What would be the effect of the EVOO dietary supplement on other MCI-related biomarkers, including vascular function and biological pathways? Researchers will compare the EVOO dietary supplements with a placebo (a look-alike substance that contains no EVOO phenolics) Participants will: * Take EVOO dietary supplements or a placebo daily for 6 months * Visit the study site during the 6-month study for screening and testing.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Have a Clinical Dementia Rating (CDR) score of 0.5 OR a Montreal Cognitive Assessment (MoCA) score of 18–25. These tests measure memory and thinking problems.

Who can't join

  • Have or have had blood vessel disease that may affect thinking.
  • Had a stroke within the past year or a transient ischemic attack (TIA, a brief stroke-like event) within the past 180 days.
  • Have had a severe, medically significant injury to the brain or spinal cord.
  • Have had a tumor inside the skull.
  • Have or have had kidney disease, with an eGFR below 60 (a measure of how well the kidneys filter blood).
  • Have a pacemaker or metal in the body.
  • Are allergic to Multihance, a contrast dye used for MRI scans.
  • Are pregnant.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * CDR (Clinical Dementia Rating) score of 0.5 OR MoCA (Montreal Cognitive Assessment) score of 18-25. Exclusion Criteria: * History or presence of vascular disease that may affect cognitive function * History or presence of stroke within the past 1 year * Recent transient ischemic attack (TIA) within the past 180 days * History of severe, clinically significant CNS trauma * History of intracranial tumor * History or presence of kidney disease (eGFR \<60 mL/min/1.73m2) * Presence of a pacemaker * Presence of metal in the body * Allergic to the MRI contrast agent "Multihance" * Pregnancy

Study sites (1)

GA