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Protoacoustic Imaging For 3D Mapping

Protoacoustic Imaging for 3D Mapping the Bragg Peak in Real Time During Proton Therapy (PROTEUS)

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not stated
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: Ultrasound, X-rays

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "This study will use special ultrasound sensors placed on the outside of the body to detect these signals."
  • "Participants enrolled in the study will first undergo standard X-ray alignment as part of their routine treatment workflow."
  • "Following alignment, a robotic arm will position an ultrasound matrix array over the lower anterior abdominal region."
  • "A conformal, water-mediated interface in combination with ultrasound gel will be used to ensure optimal acoustic coupling between the transducer and the patient's skin, allowing for passive detection of acoustic signals generated during proton beam delivery."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

The purpose of this study is to test a new imaging technology called radioacoustic imaging (RAI) that may help doctors see where radiation is being delivered during proton therapy. During proton therapy, the radiation treatment produces very small sound signals inside the body. This study will use special ultrasound sensors placed on the outside of the body to detect these signals. The information collected may allow researchers to create a picture showing where the radiation dose is being delivered in the body and how much radiation is reaching the treatment area. The goal is to determine whether this technology can safely and accurately measure radiation during proton therapy without requiring any additional procedures or radiation exposure.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: * Patients at least \>18years old * Patients referred to OUHSC SCC for SOC PT * Patients receiving treatment for indications where RAI data collection is feasible (e.g., liver and prostate) * Willingness and ability to provide a documented informed consent Exclusion Criteria: * Patients with contraindications for ultrasound coupling (e.g., extensive open wounds or skin conditions at transducer placement sites). * Patients whose treatment plan or setup prevents the practical application of the RAI system without interfering with standard clinical care * Patients with implanted electronic devices (e.g., pacemakers) in the treatment region if there is any concern of device interference, even though the RAI system is passive.

Study sites (1)

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