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State Representation in Early Psychosis 2

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
15 Years to 45 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: Interviews

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Participants will complete clinical interviews, self-report measures, cognitive assessments, computerized behavioral tasks, and EEG assessments."
  • "Participants will complete interviews, self-report measures, behavioral tasks, cognitive assessments, and electroencephalography assessments."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at thinking, behavior, and brain activity in people with early psychosis and healthy volunteers. Psychosis can make it hard to tell what is real. Participants will do interviews, surveys, thinking tests, computer tasks, and EEG tests, which record the brain’s electrical activity.

This observational study will examine behavioral and electroencephalography measures related to state representation in individuals with early psychosis and healthy control participants. Participants will complete clinical interviews, self-report measures, cognitive assessments, computerized behavioral tasks, and EEG assessments. The study will evaluate performance and computed parameters from the Translational Orientation Pattern Expectancy task and Translational Bandit Task, along with EEG variables related to cognitive control, reward processing, and neural synchrony. The study aims to better understand heterogeneity in early psychosis and identify neurocognitive and neurophysiologic markers that may inform future precision psychiatry approaches.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • All participants: Be 15 to 45 years old.
  • All participants: Be able to use English, based on your report and staff observations.
  • All participants: Have an estimated IQ of at least 70 on thinking tests.
  • All participants: Have estimated vision of 20/40 on a vision test.
  • Early psychosis group: Have a diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, unspecified psychosis, or bipolar disorder or major depression with psychosis.
  • Early psychosis group: Be 35 or younger, or be 36 to 45 with psychosis symptoms that started within the past 5 years.
  • Early psychosis group: Be stable enough to have received care outside a hospital for at least 1 month before joining.

Who can't join

  • Cannot or do not want to give informed consent, cannot make an informed choice about joining in staff’s judgment, or cannot read.
  • Have had a serious head injury or a long period of unconsciousness, as judged by the study team, or have a major brain or nervous system disorder.
  • Have had a severe alcohol or drug use disorder within 3 months before the behavior tests.
  • Have a major health condition that the study team believes would make joining difficult or unsafe.
  • Have taken part in major formal thinking-skills training programs, as judged by the study team.
  • Meet the study’s clinical criteria for risk of suicidal behavior.
  • Healthy volunteer group: Meet diagnostic criteria for a psychotic disorder or bipolar disorder.
  • Healthy volunteer group: Have a parent, sibling, or child with a psychotic disorder or bipolar disorder.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: All participants: * Aged between 15 and 45 years * English proficiency, as determined by staff observation and participant self-report * Estimated IQ at or above 70, as estimated by cognitive assessments * Estimated visual acuity at 20/40, as estimated by the visual acuity test Early Psychosis participants: * Clinical diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, psychosis NOS, bipolar disorder with psychosis, or major depressive disorder with psychosis * Age 35 years or younger, or age 36 to 45 years with onset of psychotic symptoms within the previous 5 years * Achieved clinical stability, defined as outpatient status for at least one month prior to study participation Exclusion Criteria: All participants: * Unable or unwilling to provide informed consent * Unable to demonstrate adequate decisional capacity, in the judgment of the consenting study staff member * Illiterate * Previous clinically significant head injury or prolonged unconsciousness, as determined by the investigators * Meets criteria for severe substance or alcohol use disorder within 3 months of behavioral assessment * Presence of any major medical condition that, in the opinion of the investigators, would impede participation or put the participant at additional risk * Has participated in significant formal cognitive training programs, as determined by the investigators * Meets criteria for clinical risk of suicidal behavior Early Psychosis participants: \- Presence of a major neurological disorder Healthy Control participants: * Meets DSM-5 criteria for psychotic or bipolar disorder * Has a first-degree family history of psychotic or bipolar disorder * Presence of a major neurological disorder

Study sites (2)

MN