RightFit
Not yet recruitingPhase 2

Brain Imaging of DSP-2342

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 50 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Guided by preclinical data for DSP-2342, the investigators will measure brain chemistry using magnetic resonance spectroscopy (MRS) and brain activity via task-based functional MRI (fMRI), comparing these measures before and after a single dose of DSP-2342."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests how a new drug, DSP-2342, affects how the brain works and its chemicals. It is for right-handed adults ages 18–50 who have schizophrenia.

The investigators aim to determine the effects of a novel drug on brain function and brain chemistry in patients with schizophrenia.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are right-handed, have schizophrenia, and are 18–50 years old.

Who can't join

  • You currently misuse alcohol or drugs.
  • You are pregnant or breastfeeding.
  • You have an abnormal heart electrical test, kidney or liver problems, or an uncontrolled illness that could affect thinking or safety.
  • You have or had a brain or nerve disorder, such as stroke or seizures, or have thinking problems caused by something other than schizophrenia.
  • A head injury made you pass out in the past year, or you still have problems functioning after a head injury.
  • You cannot have an MRI brain scan because of a medical implant, metal in your body or head, braces, or fear of enclosed spaces.
  • You have serious thoughts of suicide or recently had electroconvulsive therapy (treatment using electricity to cause a brief seizure).
  • Your medicines have changed in the past six weeks.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * right-handed, participants with schizophrenia between the ages of 18-50 years. Exclusion Criteria: * Current substance misuse * Pregnancy or breast feeding * Subjects with electrocardiographic abnormalities (particularly QTc prolongation) * Subjects with renal impairment * Subjects with hepatic impairment * Past or current neurological disorder (including stroke, brain tumor, epilepsy, Alzheimer's, Parkinson's or Huntington's disease) * Non-schizophrenia cause of cognitive impairment * Uncontrolled medical disorder that may interfere with cognition or compromise safety * Head trauma with loss of consciousness in the last year or any evidence of functional impairment due to and persisting after head trauma * Having a contraindication to MRI, including a pacemaker, defibrillator or other medical implant, other metal objects, or claustrophobia, or for having braces or other metal in the head region (likely to create an artifact on the MRI scans). * Significant suicidal ideation * Recent history of electroconvulsive therapy * Medication changes in the past six weeks

Study sites (1)

MD