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CT- Versus MRI-Based Planning for High-Dose-Rate Prostate Brachytherapy for Prostate Cancer

A Randomized Pragmatic Study of CT- Versus MRI-Based Planning for High-Dose-Rate Prostate Brachytherapy for Prostate Cancer

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
Male only
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: Pills, CT scans, X-rays, MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Brachytherapy is a type of radiation therapy in which radioactive implants, such as pellets, seeds, ribbons, wires, needles, balloons, or capsules, are placed in the body, directly into or near the tumor."
  • "A CT scan is a procedure that uses a computer linked to an x-ray machine to make a series of detailed pictures of areas inside the body."
  • "An MRI is a procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body."
  • "The addition of MRI to CT for HDR prostate brachytherapy treatment planning may help patients have less urine leakage and less pain after treatment."
  • "ARM A: Patients undergo treatment planning with a CT scan for HDR brachytherapy."
  • "ARM B: Patients undergo treatment planning with a CT scan and MRI scan for HDR brachytherapy."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests the safety of using CT scans, with or without MRI scans, to plan high-dose-rate radiation treatment placed inside or near the prostate. It is for men with prostate cancer that has not spread. Adding MRI may help reduce urine leakage and pain after treatment.

This clinical trial studies the safety of a computed tomography (CT) scan, with or without a magnetic resonance imaging (MRI) scan, in planning for high-dose-rate (HDR) prostate brachytherapy treatment in patients with prostate cancer. Brachytherapy is a type of radiation therapy in which radioactive implants, such as pellets, seeds, ribbons, wires, needles, balloons, or capsules, are placed in the body, directly into or near the tumor. The radiation is delivered through a flexible tube called a catheter or a larger device called an applicator. Treatment planning, or simulation, is a process used to plan radiation therapy so that the target area is precisely located and marked. A CT scan is a procedure that uses a computer linked to an x-ray machine to make a series of detailed pictures of areas inside the body. The pictures are taken from different angles and are used to create 3-dimensional views of tissues and organs. An MRI is a procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body. The addition of MRI to CT for HDR prostate brachytherapy treatment planning may help patients have less urine leakage and less pain after treatment.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Men age 18 or older.
  • Prostate cancer confirmed by testing a tissue sample.
  • No signs that cancer has spread to nearby lymph nodes or distant parts of the body.
  • Planning to have high-dose-rate brachytherapy, radiation placed inside or near the prostate, with the goal of curing the cancer. Radiation from a machine outside the body may also be planned.

Who can't join

  • Have had radiation treatment to the pelvis, the lower belly area.
  • Have not had an MRI scan of the prostate before.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Men ≥ 18 years old * Histopathologically confirmed prostate cancer * No evidence of regional or distant metastases * Plan to undergo curative-intent HDR brachytherapy with or without external beam radiation therapy Exclusion Criteria: * Prior pelvic radiation therapy * No prior prostate MRI

Study sites (3)

GA