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RecruitingPhase 1 / Phase 2

Tributyrin for Progressive Supranuclear Palsy (PSP): Virtual Trial

Tributyrin for PSP: Phase 1b Virtual Trial - Feasibility Study

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
45 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This virtual study tests tributyrin, a supplement, in people with progressive supranuclear palsy (PSP). It looks at safety, how well people tolerate the supplement, and whether taking it and doing tests online is practical for people with PSP.

This research is studying a supplement called tributyrin in people with Progressive Supranuclear Palsy (PSP) to learn about its safety and tolerability as a potential treatment. The goal of this research study is to see if a similar supplementation regimen and virtual testing is feasible for people with PSP.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Age 45 or older.
  • Have a diagnosis of PSP-Richardson syndrome that meets Movement Disorder Society rules.
  • Have trouble moving your eyes up and down.
  • Have repeated falls without a clear cause, or tend to fall during a pull test, within 3 years.
  • Have internet access and a webcam for online visits.
  • Have a caregiver.

Who can't join

  • Have a recent history of serious, uncontrolled digestive disease, such as acid reflux or colon or rectal cancer.
  • Have a serious disorder affecting how your body uses energy, or another uncontrolled medical condition.
  • Regularly take typical anticholinergic drugs, which block a nerve signal in the body.
  • Are a woman who could become pregnant, is pregnant, or is breastfeeding.
  • Have thoughts of suicide shown by a score of 2 or 3 on question 9 of the Beck Depression Inventory, a depression survey.
  • Have any other condition that the study team thinks would prevent safe and meaningful participation.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Male or Female, age 45 years and over. * Diagnosis of PSP-Richardson syndrome (RS) based on Movement Disorder Society (MDS) Criteria, including 1. Vertical supranuclear gaze palsy. 2. Repeated unprovoked falls OR tendency to fall on the pull test within 3 years. * Access to the internet and webcam for virtual visits. * Presence of a caregiver. Exclusion Criteria: * Recent history of significant, uncontrolled GI disease such as Gastroesophageal reflux disease, colorectal cancer. * Significant metabolic or uncontrolled medical comorbidity. * Regular use of typical anti-cholinergic drugs. * Women of child-bearing potential, or who are pregnant and/or nursing. * Suicidal ideation, as indicated by a response of 2 or 3 on question 9 of the Beck Depression Inventory. * Any other condition or criterion that, in the opinion of the investigators, would preclude safe and meaningful participation in the study.

Study sites (1)

MI