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Feasibility and Acceptability of Remote Saliva Collection

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
8 Years to 18 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Time periods mentioned: 3 days
  • Procedures mentioned: Questionnaires, Blood draws

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Participants will provide saliva, blood, hair, and fingernail samples, complete questionnaires, and participate in sleep monitoring."
  • "Primary Objective \- To evaluate the feasibility of collecting multiple biological specimens, surveys, and sleep assessment among child and adolescent survivors of ALL and their siblings."
  • "Saliva samples will be collected at home five times per day over three days."
  • "Questionnaires will assess demographic information, sleep, emotional well-being, family relationships, health behaviors, and other factors that may influence cortisol measurements."
  • "Caregivers will complete questionnaires about household and demographic characteristics and provide feedback regarding study acceptability."
  • "Blood samples will be used to measure markers of inflammation and hormone function."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

The purpose of this study is to evaluate the practicality and acceptability of collecting biological samples and health information from childhood survivors of acute lymphoblastic leukemia (ALL) and their siblings. Participants will provide saliva, blood, hair, and fingernail samples, complete questionnaires, and participate in sleep monitoring. The information collected will help researchers understand how cancer treatment and neighborhood conditions may affect stress hormones, inflammation, and long-term health. Primary Objective \- To evaluate the feasibility of collecting multiple biological specimens, surveys, and sleep assessment among child and adolescent survivors of ALL and their siblings.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: SURVIVORS * The survivor is a childhood survivor of Acute Lymphocytic Leukemia (ALL). * The survivor was treated on one of the following St. Jude Total Therapy Studies: 1. TOTAL Therapy study XVI for Newly Diagnosed Patients with ALL (TOTXVI) OR 2. Total Therapy for Children with Acute Lymphoblastic Leukemia and Lymphoma (TOT17) * The survivor is cancer-free. * The survivor is at least 5 years out from the ALL diagnosis. * The survivor is at least 2 years out from completion of treatment. * The survivor did not receive cranial therapy as part of ALL therapy. * The survivor is aged ≥8 to 18 years old at the time of enrollment. * The survivor has completed their After Completion of Therapy (ACT) clinic consultation. * The survivor is able to speak and read English. * The survivor has internet access. SIBLINGS * The sibling has a brother or sister who is an ALL survivor participating in this study. * The sibling is aged ≥8 to18 years old at the time of enrollment. * The sibling is able to speak and read English. * The sibling has internet access. CAREGIVERS * The caregiver provides primary care or support to an ALL survivor that is in this study. * The caregiver resides in the home full-time with enrolled survivor and sibling. * The caregiver is able to speak and read English. * The caregiver has internet access. * The caregiver is willing and able to assist with at home biospecimen collection. Exclusion Criteria: SURVIVORS and SIBLINGS * Survivor and/or sibling has a diagnosis of Down's Syndrome. * Survivor and/or sibling has a diagnosis of autism spectrum disorder. * Survivor and/or sibling has a diagnosis of another pervasive developmental disorder not listed above. * Survivor and/or sibling has a history of prolonged treatment with steroid medications or systemic glucocorticoids for reasons other than ALL. * Survivor and/or sibling resides outside of the United States. * Inability or unwillingness of survivor and/or sibling and/or legal guardian/representative to give written informed consent. CAREGIVERS Note: There are no exclusion criteria for caregivers.

Study sites (1)

TN