Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 18 Years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
- Compensation
- Mentioned in the study description
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
- Time periods mentioned: 2 years
- Procedures mentioned: Blood draws
Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.
Show the study's own words
- "By checking levels of these markers every 3 months (+/- one month) in stable HF patients for two years, our goal is to see if those with a "spike" in level predict adverse outcome in CHF."
- "We will also obtain blood samples from control subjects to measure baseline levels and determine if there are diurnal rhythm variations."
- Compensation
- Mentioned in the study description
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
In plain language
This study checks whether two proteins in the blood rise during sudden or worsening heart failure. It is for adults with heart failure and healthy adults for comparison. Researchers do not yet know if higher levels of these proteins are linked to heart failure or any disease.
The purpose of this research is to determine if two proteins in the blood are increased during acute heart failure. These two proteins are produced when the heart becomes dysfunctional and unable to contract normally. They may then be released into the blood and be detected by standard method in the research laboratory. Thus, the purpose of this study is to determine the relation between the change of these two proteins in the blood and the occurrence of acute heart failure. At this time, detection of an increase in these proteins in the blood is not known to be associated with any disease or heart failure.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Who can join
- You must be older than 18.
- People with stable or worsening heart failure may join, no matter how much blood their heart pumps with each beat.
- Signs of worsening heart failure include trouble breathing, crackling lung sounds, swelling, raised pressure in neck veins, or fluid in the belly.
- Heart images show signs of heart failure, such as an enlarged heart, weak pumping, trouble relaxing between beats, or high pressure as the heart fills.
- Healthy people with no past heart attack or heart failure may join as a comparison group.
- Pregnancy does not keep you from joining.
Who can't join
- You cannot give informed consent, which means understanding the study and agreeing to join.
- You had any surgery in the 3 months before joining.
Simplified for readability. The official criteria below are what the study team uses.
Official eligibility criteria
Inclusion Criteria: * Individuals aged \>18yrs * stable or decompensated heart failure, irrespective of LVEF * decompensated heart failure clinical symptoms such as dyspnea, rales, edema, elevated jugular venous pressure, or ascites * Imaging evidence of heart failure (cardiomegaly, poor contractile function or echocardiographic Doppler evidence of diastolic dysfunction or elevated right- or left-sided filling pressures) * Healthy individuals with no prior history of heart attack or heart failure will be recruited to use as controls. Exclusion Criteria: * Subjects who are unable to give informed consent * Subjects who had undergone cardiac or non-cardiac surgery in the 3 months before enrollment * Pregnant subjects are not excluded
Study sites (1)
CT
- University of Connecticut Health Center · Farmington, CT 06030More trials in Farmington