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Identification of Phenotypic Factors That Predict Success for Weight Loss and Long-term Weight Maintenance

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
15 Years to 75 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at body traits that may help predict who will lose weight and keep it off. It is part of a University of Michigan program that explores ways to manage weight over time. The study includes people with higher and lower body mass index (BMI), a measure based on height and weight.

The Investigational Weight Management Clinic now entitled the Weight Management Program at the University of Michigan was created to identify strategies that will result in cost-effective, long term weight management for overweight and obese individuals. The driving hypothesis of the clinic is that the 'one size fits all' philosophy is untenable with a complex disease such as obesity. The clinic will serve as a portal for patients to choose standard clinical care or to explore alternatives from a variety of clinical studies offered through the clinic. These studies will include further investigations into nutrition, the biological basis of weight and weight management and protocols using approved and experimental pharmaceuticals as well as technologies that aid in self-management of weight.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • For the higher-weight group: men and women older than 20 with a BMI of 27 or higher.
  • For the lower-weight group: BMI above 17 but below 27.
  • Able and willing to give written consent to join the study.
  • Women who can become pregnant must use reliable birth control.

Who can't join

  • An inherited problem with how the body handles fats; cancer in the past 5 years; a positive HIV antibody test; or a solid organ transplant.
  • Pregnant or breastfeeding, or took part in another clinical trial within 90 days before joining.
  • Thyroid disease that is not controlled; unstable angina (heart-related chest pain); or heart failure rated class II or higher, meaning symptoms with activity or worse.
  • A digestive disease, especially problems moving food through the gut; end-stage kidney or liver disease; or an autoimmune disease, such as lupus, where the body attacks its own tissues.
  • An unstable brain or mental health condition, including major depression, anxiety, or an eating disorder such as binge eating, bulimia, or anorexia.
  • Weight changed by more than 5 kg (about 11 pounds) in the past 3 months, or past weight-loss surgery.
  • Past or current alcohol or drug abuse, or changed smoking habits or quit smoking in the past 6 months.
  • Unable or unwilling to consent, or any condition the study doctor thinks would make joining unsafe or prevent taking part or finishing.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Obese males and females: age \>20 years; Obese population defined as BMI \> or = 27 kg/m2 * Lean population BMI \< 27 but \> 17 kg/m2 * Able and willing to provide written informed consent for the trial Exclusion Criteria: * Evidence of inherited disorders of lipid metabolism. * History of Cancer within the last 5 years * Human immunodeficiency virus (HIV) antibody positive. * Patients with solid organ transplants. * Participation in any other clinical trial within 90 days of entry into this trial. * Pregnant or lactating females. * Uncontrolled thyroid disease * Unstable angina or NY heart association class II failure or above * Gastrointestinal disease specifically GI motility disorders * Unstable neuropsychiatric disease including major depression/anxiety, eating disorder such as binge eating, bulimia or anorexia * End stage renal or hepatic disease * Autoimmune disorders (e.g. SLE) * Body weight fluctuation of more than 5 kg in the previous 3 months * Prior bariatric surgery * A history or current alcohol/substance abuse and change in smoking habits or cessation in the past 6 months. * Women of childbearing age must use a reliable form of contraception. * Any medical condition, which in the opinion of the investigator would make the patient unsuitable for recruitment, or could interfere with the patient participating in or completing the protocol. * Unwilling or unable to consent for the study.

Study sites (1)

MI