Obesity clinical trials

371 recruiting studies in the US for obesity, a complex chronic condition involving excess body weight.

Obesity research here is mostly lifestyle, nutrition and behavioral programs, with a growing set of drug trials for newer weight-management medicines. Studies usually set a BMI range, and some require a weight-related condition such as prediabetes or sleep apnea. Expect questions about recent weight changes and any weight-loss medicines or surgery.

Top locations

By phase

Showing 40 of 371 studies

RecruitingNot applicableNCT06067451

SMART GOALS for Youth With Prediabetes

Sponsor: Northwell Health

New York, NY

RecruitingPhase 3NCT07654374

A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

Sponsor: Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

Birmingham, AL · Chandler, AZ · Phoenix, AZ · +71 more sites

RecruitingPhase 2NCT07752979

Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities

Sponsor: AbbVie

Pelham, AL · Scottsdale, AZ · Tucson, AZ · +56 more sites

RecruitingPhase not listedNCT02769975

Evaluation of Children With Endocrine and Metabolic-Related Conditions

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Bethesda, MD

RecruitingNot applicableNCT07792226

ENLIGHT Trial: ESG With Fundal Mucosal Ablation

Sponsor: West Virginia University

Morgantown, WV

RecruitingPhase not listedNCT03481829

Early Tracking of Childhood Health Determinants (ETCHED) Study

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Phoenix, AZ

RecruitingNot applicableNCT05124808

Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes

Sponsor: Indiana University

Birmingham, AL · Indianapolis, IN · Norman, OK · +2 more sites

RecruitingPhase 2NCT06273072

Metformin IN Asthma for Overweight and Obese Individuals (MINA)

Sponsor: Johns Hopkins University

Baltimore, MD · Houston, TX

RecruitingNot applicableNCT06690788

PreventT2 Together: Examining the Efficacy of Couple-based Lifestyle Intervention to Prevent Type 2 Diabetes

Sponsor: University of Utah

Salt Lake City, UT

RecruitingNot applicableNCT07238556

A Novel Digital Tool Clinicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors

Sponsor: University of Connecticut

Farmington, CT · Hartford, CT · Storrs, CT

RecruitingPhase 1NCT07868354

A Research Study Investigating How Adults With Overweight or Obesity, With or Without Type 2 Diabetes, Tolerate Switching to a New Treatment (Zenagamtide) From Their Current Tirzepatide Medication

Sponsor: Novo Nordisk A/S

Glendale, CA · Baltimore, MD

RecruitingPhase not listedNCT06007404

Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

Sponsor: University of Michigan

Ann Arbor, MI

RecruitingPhase not listedNCT06604650

Community Park-Based Programs for Health Promotion: Active Older Adults Prospective Cohort Study

Sponsor: Duke University

Miami, FL

RecruitingNot applicableNCT06970457

The Interaction of Body Composition, Sex Hormones and Exercise in Men

Sponsor: Oklahoma State University

Stillwater, OK

RecruitingPhase 2NCT07837973

Study to Assess the Effect and Safety of ALV-100 on Maintenance of Weight Loss

Sponsor: Alveus Therapeutics, Inc.

Birmingham, AL · Sun City, AZ · Tempe, AZ · +17 more sites

RecruitingPhase 3NCT07845500

A Study to Learn About Switching to a Monthly Study Medicine Called Berobenatide (PF-08653944) to Help Keep Weight Off in People With Overweight or Obesity

Sponsor: Pfizer

Birmingham, AL · Los Angeles, CA · Santa Ana, CA · +13 more sites

RecruitingNot applicableNCT06364644

Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure

Sponsor: Johns Hopkins University

Baltimore, MD · Hagerstown, MD

RecruitingPhase 1NCT06414096

Use of Pulsatile Intravenous FSH to Mitigate Reprometabolic Syndrome

Sponsor: University of Colorado, Denver

Aurora, CO

RecruitingPhase not listedNCT01143454

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Washington D.C., DC · Bethesda, MD

RecruitingNot applicableNCT03288207

Tailoring Mobile Health Technology to Reduce Obesity and Improve Cardiovascular Health in Resource-Limited Neighborhood Environments

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Bethesda, MD

RecruitingPhase not listedNCT04714892

Mechanisms Underlying Individual Variations of Taste and Smell in Obesity

Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Bethesda, MD

RecruitingPhase 3NCT07351045

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

Sponsor: Hoffmann-La Roche

Anniston, AL · Birmingham, AL · +41 more sites

RecruitingPhase 3NCT07595549

A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

Sponsor: Pfizer

Canoga Park, CA · Escondido, CA · Modesto, CA · +32 more sites

RecruitingPhase 3NCT07667803

A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM

Sponsor: AstraZeneca

Birmingham, AL · Dothan, AL · Chandler, AZ · +53 more sites

RecruitingPhase 2NCT07685808

Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without Diabetes

Sponsor: Regeneron Pharmaceuticals

Mobile, AL · Walnut Creek, CA · Waterbury, CT · +18 more sites

RecruitingPhase 3NCT07823608

A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Use a Breathing Machine (PAP) (VESPER-OSA 1)

Sponsor: Pfizer

Cullman, AL · Riverside, CA · Bradenton, FL · +3 more sites

RecruitingPhase 2NCT06897475

A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide

Sponsor: Eli Lilly and Company

Phoenix, AZ · Santa Ana, CA · Ocala, FL · +22 more sites

RecruitingPhase not listedNCT03025074

Blood Collection Biorepository for Liver Disease Research

Sponsor: State University of New York at Buffalo

Buffalo, NY

RecruitingPhase 3NCT07037433

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

Sponsor: Amgen

Daphne, AL · Fairhope, AL · Huntsville, AL · +137 more sites

RecruitingNot applicableNCT07478653

MODERN-Dental: Pediatric Obesity, Cardiometabolic Risks, And Periodontal Disease

Sponsor: Oelisoa Andriankaja

Lexington, KY

RecruitingPhase 2NCT07589608

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

Sponsor: Eli Lilly and Company

Chandler, AZ · Scottsdale, AZ · Tucson, AZ · +37 more sites

RecruitingPhase 2NCT07783802

A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event

Sponsor: Eli Lilly and Company

Huntsville, AL · Tucson, AZ · +27 more sites

RecruitingPhase 3NCT07794579

A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity

Sponsor: Eli Lilly and Company

Anniston, AL · Birmingham, AL · Pelham, AL · +77 more sites

RecruitingPhase 1NCT07808073

A Study of LY4329090 in Participants With Obesity or Overweight Who Are Otherwise Healthy

Sponsor: Eli Lilly and Company

Daytona Beach, FL · Dallas, TX

RecruitingNot applicableNCT01399385

New Heart Imaging Techniques to Evaluate Possible Heart Disease

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Bethesda, MD

RecruitingPhase not listedNCT05632406

Breathing & Blood Pressure

Sponsor: Florida State University

Tallahassee, FL

RecruitingPhase 2NCT06143956

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

Sponsor: Eli Lilly and Company

Chandler, AZ · Phoenix, AZ · Scottsdale, AZ · +47 more sites

RecruitingPhase 3NCT06937086

Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

Sponsor: Eli Lilly and Company

Dothan, AL · Anaheim, CA · Beverly Hills, CA · +34 more sites

RecruitingPhase 3NCT06937099

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

Sponsor: Eli Lilly and Company

Dothan, AL · Anaheim, CA · Beverly Hills, CA · +32 more sites

RecruitingPhase 2NCT07282340

Phentermine's Impact on Treatment in Teens

Sponsor: Russell McCulloh, MD

Wilmington, DE · Louisville, KY · Baton Rouge, LA · +5 more sites

Related conditions

Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.