Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)
Immunoinflammatory and Metabolic Responses in Post Cardiac Arrest Syndrome (PCAS)
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 18 Years and older
- Sex
- All sexes
- Healthy volunteers
- Accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after cardiac arrest. Investigators have shown that cardiac arrest induces changes in the numbers and properties of circulating immune cells, shifting the balance towards a pro-inflammatory phenotype and there is increased interest in the inflammatory pathways and the signaling mechanisms through which they are modulated. Participants will undergo blood sampling during 7 days following cardiac arrest, and analyses performed. Patient characteristics, clinical circumstances, and outcomes will be recorded and their associations with these inflammatory pathways characterized.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Official eligibility criteria
Inclusion Criteria: * Aged 18 years or older * Admitted to the intensive care unit after cardiac arrest episode * Unresponsive after resuscitation Exclusion Criteria: * Moribund / actively dying at the time of evaluation * Informed consent cannot be obtained within 24 hours of resuscitation * Hemoglobin less than 7.0 g/dL, active high-volume bleeding, or requiring a transfusion
Study sites (1)
ME
- Maine Medical Center · Portland, ME 04102David B Seder, MD · Study contact · 207-662-2179 · david.seder@mainehealth.orgSergey Ryzhov, MD, PhD · Study contact · Sergey.ryzhov@mainehealth.orgDavid J Gagnon, PharmD · Sub-investigatorDavid B Seder, MD · Principal investigatorMore trials in Portland