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Phenotyping Genetic Risk for Type 2 Diabetes

Phenotyping Children and Adults With Possible High or Low Genetic Risk for Type 2 Diabetes

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
10 Years to 70 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: X-rays

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Each participant will undergo a frequently sampled four-hour oral glucose tolerance test and whole body DXA scan (dual-energy X-ray absorptiometry) in addition to baseline laboratory and history assessment."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at people without diabetes who have a high or low risk of type 2 diabetes based on their genes. It tests whether those at higher risk have more trouble handling blood sugar and using insulin, a hormone that controls blood sugar.

This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are 10 to 70 years old.
  • You took part in the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be contacted about future research.
  • Adults must have a body mass index (BMI), a measure of weight compared with height, of 25 or higher. Children and teens must have a BMI at or above the 85th percentile.

Who can't join

  • You have been diagnosed with type 1, type 2, or secondary diabetes (diabetes caused by another condition).
  • You take medicines that affect blood sugar or insulin, such as steroids, metformin, or other diabetes medicines.
  • You have a short-term illness that may affect blood sugar or insulin, or you are pregnant.
  • You have hypothalamic obesity (obesity linked to a part of the brain) or a related genetic disorder that affects how your body uses energy.
  • You recently had chemotherapy that treats the whole body.
  • You have a stomach or bowel problem, or had surgery, that may affect how your body absorbs food.
  • You have anemia (too few healthy red blood cells).
  • You have a major organ illness or a condition needing regular treatment that could make the study or its results hard to manage, or you cannot follow the study steps.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Age 10-70 years * Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research. * Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher Exclusion Criteria: * prior diagnosis of type 1, type 2, or secondary diabetes * use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication * acute illness that may impact insulin and glucose dynamics * pregnancy * hypothalamic obesity or related genetic disorder of metabolism * recent systemic chemotherapy use * gastrointestinal impairment or surgery that may impact absorption * anemia * major organ system illness or any underlying condition requiring regular medication or treatment that could make implementation of the protocol or interpretation of the study results difficult * inability to comply with study protocol

Study sites (2)

PA