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Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity

Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity- AIM 1

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
30 Years to 70 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how swelling and irritation in body fat are linked to fat buildup around the liver and changes in how the liver looks and works. It also looks at how these changes affect the body's response to insulin, which helps control blood sugar. It is for adults with obesity who are having gastric bypass surgery.

This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin resistance.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Having gastric bypass surgery.
  • A confirmed liver scarring test result of F=0 or F greater than 2.
  • Age 30 to 70.
  • Body mass index (BMI), a measure of weight compared with height, above 40.
  • A negative pregnancy test, for women only.
  • Normal TSH, a hormone that helps control the thyroid gland.

Who can't join

  • An autoimmune disease, where the body's defenses attack healthy cells.
  • A positive test for hepatitis B or C, viruses that can harm the liver.
  • Heavy alcohol use.
  • Currently smoking.
  • Active cancer.
  • A history of asthma or COPD, lung diseases that affect breathing.
  • Taking Plavix or Coumadin, medicines that help prevent blood clots; taking glucocorticoids, a type of steroid; or regularly taking antihistamines, often used for allergies.
  • Donated blood in the past 2 months.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Undergoing gastric bypass surgery * Confirmed AUROC F=0 or F\>2 liver fibrosis * Age 30-70 years * BMI greater than 40 kg/m2 * Negative pregnancy test (female only) * Lab Values: Normal TSH Exclusion Criteria: * Autoimmune diseases * Hepatitis B or C positive * Heavy alcohol use * Active smoking history * Active cancer history * History of asthma * History of COPD * Taking Plavix or Coumadin * Blood donation within past 2 months * Glucocorticoid Therapy * Taking antihistamine on regular basis

Study sites (1)

AZ