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The Early and Late Contribution of Fasting and Postprandial Triglycerides on Newborn Subcutaneous and Intrahepatic Fat in Pregnancy

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
0 Years to 39 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Two weeks after birth, infants will have total fat measured by air-displacement plethysmography (PEAPOD) and liver fat measures by Magnetic Resonance Spectroscopy (MRS)."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at whether a mother's blood fat levels, called triglycerides, during pregnancy predict her baby's body and liver fat. It is for pregnant women ages 21–39 with a pre-pregnancy BMI of 28–39. Mothers will check blood fat and blood sugar at home, and babies will have fat measured two weeks after birth.

This study plans to learn more about how triglyceride levels in pregnancy affect newborn fat mass. Obesity in pregnancy, in the absence of gestational diabetes, is now the most common cause of large-for-gestational-age infants and increased newborn fat mass. Previous data supports the idea that maternal triglycerides, not glucose, are the strongest predictor of both total newborn fat mass and liver fat. In this study, mothers will monitor triglyceride and glucose levels at specific points in pregnancy using point-of-care meters at home. Two weeks after birth, infants will have total fat measured by air-displacement plethysmography (PEAPOD) and liver fat measures by Magnetic Resonance Spectroscopy (MRS). The central hypothesis is that in obesity, fasting triglycerides and postprandial triglycerides will predict newborn fat mass in a free-living environment.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Less than 16 weeks pregnant.
  • Ages 21–39.
  • Before pregnancy, a body mass index (BMI) of 28–39. BMI is a measure based on height and weight.

Who can't join

  • Diabetes or prediabetes before pregnancy. Prediabetes means blood sugar is higher than normal.
  • Past diabetes during pregnancy.
  • Past pre-eclampsia, a serious pregnancy condition involving high blood pressure.
  • Past birth that started on its own too early.
  • Past high blood pressure caused by pregnancy before 34 weeks.
  • Tobacco or illegal drug use.
  • Long-term use of steroid medicines.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Pregnant women less than 16 weeks gestational age * Between the ages of 21-39 years * Pre-pregnancy BMI 28-39 kg/m2 Exclusion Criteria * Pre-gestational diabetes or prediabetes * History of gestational diabetes * History of pre-eclampsia, spontaneous pre-term delivery, or gestational hypertension \<34wks * Tobacco or illicit substance use * Chronic steroid use

Study sites (1)

CO