RightFit
RecruitingPhase 1 / Phase 2

Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)

Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
35 Years to 65 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether vitamin C helps blood vessels work better and lowers blood pressure. It is for adults ages 35–65 with obesity and insulin resistance, which means the body does not respond well to insulin. Researchers also study the nerves that control blood vessels.

The main purpose of research is to examine and understanding the development of hypertension in obese adults with insulin resistance. Findings from our studies will identify unique mechanisms that can be targeted to limit increases in vascular dysfunction and reduce the excessively high prevalence of hypertension and risk for cardiovascular disease (CVD). This study is testing the health of the blood vessels and the activity of the nerves that control the blood vessels in adults with insulin resistance. The extent to which ascorbic acid (Vitamin C) improves the function of the blood vessels will be determined. The primary outcome is blood pressure, which is the result of blood vessel health and activity of the nerves, and the reduction in blood pressure that is observed with ascorbic acid.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Have obesity, with a body mass index (BMI) over 30. BMI is a measure based on height and weight.
  • Be 35–65 years old.
  • Be willing and able to stop vitamin C, vitamin E, and omega-3 supplements starting 2 weeks before the study.
  • Be willing and able to sign a form agreeing to take part.

Who can't join

  • Have diabetes. The blood sugar limits written in the listing appear to have errors; ask the study team to confirm.
  • Currently take a statin to lower cholesterol or medicine for high blood pressure.
  • Have high blood fats. The listed blood fat limit does not match this description; ask the study team to confirm.
  • Have high blood pressure. The listed blood pressure limit does not match this description; ask the study team to confirm.
  • Have a history of heart disease, such as a heart attack or a stent placed to keep an artery open.
  • Have a history of blood vessel disease, such as bypass surgery or a stroke.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: 1. Obese: BMI \>30 m/kg2 2. Middle-aged: 35-65 years 3. Participants must be willing and able to discontinue taking any vitamin C or E supplements or omega-3 fatty acids beginning 2 weeks prior. 4. Able and willing to provide written informed consent Exclusion Criteria: 1. Diabetes mellitus: fasting glucose \< 1267 mg/dL and/or HbA1c \< 6.5% 2. Currently taking a statin or antihypertension medication 3. Hyperlipidemia: Fasting triglycerides \< 250 mg/dL 4. Hypertension: \<130/80 mmHg 5. History of heart disease (e.g., myocardial infarction, stent) 6. History of vascular disease (e.g., bypass, stroke)

Study sites (1)

KS