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Neural Correlates of Stress and Perceived Control in Adolescent Depression

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
14 Years to 18 Years
Sex
Female only
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: MRI scans, Questionnaires, Interviews

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "The study will include four sessions: * A clinical diagnostic interview as well as filling out a series of questionnaires and assessments. * The second session will include a functional magnetic resonance imaging (fMRI) brain scan to be conducted at the McLean Hospital Imaging Center."
  • "Participants will be asked to respond to surveys on their cell phone in the week following the fMRI brain scan. * The third session will include a diagnostic interview, assessments, and questionnaires to be completed three-months after the fMRI brain scan."
  • "Participants will be asked to complete surveys on their cell phone during the week following this three month follow-up session. * The fourth session will include a diagnostic interview, assessments, and questionnaires to be completed six-months after the fMRI brain scan."
  • "Participants will be asked to complete surveys on their cell phone during the week following this six month follow-up session."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived control disruptions in MDD remain poorly understood. Using functional magnetic resonance imaging with a novel "value of control task" in conjunction with a prospective design, this study will provide a comprehensive understanding of stress and perceived control related mechanisms in female adolescents with MDD and will examine stress-induced disruptions in perceived control as a predictor of "real world" expressions of maladaptive coping and anhedonia.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: * Inclusion Criteria: All Participants 1. Females of all ethnic origins See Section: Inclusion of Women and Minorities); 2. Ages 14-18 (See Section: Inclusion of Children); 3. Written informed assent/consent from adolescent and parent/guardian (if under age 18); 4. English as a first language or English fluency; 5. Right handed111; 6. Personal cell-phone (for Ecological Momentary Assessment \[EMA\]) 7 All participants will be in the follicular phase of their menstrual cycle when completing the functional magnetic resonance imaging (fMRI) study session Inclusion Criteria: MDD Sample 1. Meet Diagnostic Statistical Manual-5th edition (DSM-5) diagnostic criteria for major depressive disorder (as diagnosed with the KSADS) 2. Absence of any psychotropic medications for at least 2 weeks (6 weeks for fluoxetine; 6 months for neuroleptics; 2 weeks for benzodiazepines; 2 weeks for any other antidepressants); Inclusion Criteria: Healthy Control (HC) Sample 1. No history or current diagnosis of any DSM-5 psychiatric or substance/alcohol-related disorder (as diagnosed with the KSADS) 2. No first-degree relatives with a history of depression, bipolar disorder, or psychosis Exclusion Criteria: * Exclusion Criteria: All Participants 1. History of head trauma with loss of consciousness; 2. History of seizure disorder; 3. Serious or unstable medical illness including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease; 4. History of cocaine or stimulant use (e.g., amphetamine, cocaine, methamphetamine); 5. History of use of dopaminergic drugs (including methylphenidate); 6. Use of hormonal replacement therapy, anabolic steroids, or hormonal contraception; 7. Clinical or laboratory evidence of hypothyroidism; 8. Systemic medical or neurological illness that could impact fMRI measures of cerebral blood flow; 9. Failure to meet standard exclusion criteria for fMRI scanning (e.g., claustrophobia, cardiac pacemakers, neural pacemakers, surgically implanted metal devices, cochlear implants, metal braces, or other metal objects in the body); 10. Pregnancy 11. Testing positive on a drug test on the day of the scan which testis for stimulants, marijuana, barbiturates, benzodiazepine, buprenorphine, 3,4-Methyl enedioxy methamphetamine (MDMA), methadone, opiates, oxycodone, phencyclidine; 12. History of electroconvulsive therapy 13. Participants with suicidal ideation where study participation is deemed unsafe by the study clinician; Additional Exclusion Criteria: Major Depressive Disorder (MDD) Sample 1\. Major depressive disorder diagnosis secondary to another disorder (selected comorbid anxiety disorders such as generalized anxiety disorder, specific phobia, and social anxiety disorders are allowed if they are secondary to MDD)

Study sites (1)

MA