Depression clinical trials

461 recruiting studies in the US for depression, a common mood disorder affecting how people feel and function.

Most depression studies listed here are behavioral or device studies — talk therapy formats, digital apps, brain stimulation — rather than phased drug trials. Drug trials that do appear often focus on treatment-resistant depression or fast-acting medicines. Studies typically ask about current medications and safety screening questions before enrollment.

Top locations

By phase

Showing 40 of 461 studies

RecruitingPhase 1NCT03065335

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

Sponsor: National Institute of Mental Health (NIMH)

Bethesda, MD

RecruitingNot applicableNCT07478393

Readiness and Progress in Emotion Regulation Therapy

Sponsor: Teachers College, Columbia University

New York, NY

RecruitingNot applicableNCT07042217

Transcranial Direct Current Stimulation for Depression

Sponsor: Soterix Medical

Woodbridge, NJ

RecruitingNot applicableNCT07842432

Improving Student Mental Health Through a Universal Trauma-Informed Intervention

Sponsor: Johns Hopkins Bloomberg School of Public Health

Baltimore, MD

RecruitingNot applicableNCT05645575

In-patient SCC TMS

Sponsor: University of California, Los Angeles

Los Angeles, CA

RecruitingNot applicableNCT06423430

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

Sponsor: Abbott Medical Devices

Birmingham, AL · Los Angeles, CA · +23 more sites

RecruitingNot applicableNCT06627764

SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Families

Sponsor: Duke University

Durham, NC

RecruitingPhase 2NCT07219875

Training Reward Responsiveness Through Virtual Reality

Sponsor: University of California, Los Angeles

Los Angeles, CA

RecruitingNot applicableNCT07876908

SAINT® Therapy for Memory Problems in Older Adults With Treatment-Resistant Depression

Sponsor: BrainHealth Solutions, Inc.

Costa Mesa, CA

RecruitingPhase 2NCT06188923

A New Intervention to Improve Function in Veterans With Anxiety and Depression

Sponsor: VA Office of Research and Development

Durham, NC

RecruitingPhase 3NCT07592689

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

Sponsor: Definium Therapeutics US, Inc.

Little Rock, AR · Orange, CA · San Diego, CA · +27 more sites

RecruitingPhase 2NCT07610473

A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

Sponsor: Draig Therapeutics Ltd

Phoenix, AZ · Little Rock, AR · Bellflower, CA · +20 more sites

RecruitingNot applicableNCT07865052

Psychological Prehabilitation for Complex Gastrointestinal Surgery

Sponsor: Northwestern University

Chicago, IL

RecruitingNot applicableNCT05487911

Cortical rTMS as a Treatment for Depression

Sponsor: Baylor College of Medicine

Houston, TX

RecruitingPhase 2NCT06656416

ALTO-100 in Bipolar Disorder With Depression (BD-D)

Sponsor: Alto Neuroscience

Birmingham, AL · Chandler, AZ · Phoenix, AZ · +55 more sites

RecruitingNot applicableNCT06907654

Couples' Affect in Relationships Study

Sponsor: University of Wisconsin, Madison

Madison, WI

RecruitingPhase 3NCT07484217

Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol

Sponsor: Axsome Therapeutics, Inc.

Tucson, AZ · Bellflower, CA · Chino, CA · +37 more sites

RecruitingPhase 1NCT06675240

Meditative Neurofeedback for Depression

Sponsor: University of California, San Diego

La Jolla, CA

RecruitingNot applicableNCT06654414

Adapting and Pilot Testing a Skills-based Smoking Cessation Intervention to Address Developmental and Health-related Stress Among Adults Who Smoke

Sponsor: Massachusetts General Hospital

Boston, MA

RecruitingPhase 2NCT07300969

A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

Sponsor: Draig Therapeutics Ltd

Bentonville, AR · Little Rock, AR · Oceanside, CA · +20 more sites

RecruitingPhase not listedNCT05669703

NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder

Sponsor: National Institute of Mental Health (NIMH)

Bethesda, MD

RecruitingEarly Phase 1NCT06788249

Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine

Sponsor: University of Pennsylvania

Philadelphia, PA

RecruitingNot applicableNCT07143357

Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest

Sponsor: Icahn School of Medicine at Mount Sinai

Boston, MA · New York, NY

RecruitingNot applicableNCT07211217

Time Restricted Eating (TRE) in Bipolar Disorder

Sponsor: Massachusetts General Hospital

Boston, MA

RecruitingPhase 3NCT07775300

A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder

Sponsor: Eli Lilly and Company

Birmingham, AL · Phoenix, AZ · Irvine, CA · +31 more sites

RecruitingPhase 2NCT07284667

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

Sponsor: ACADIA Pharmaceuticals Inc.

Birmingham, AL · Chino, CA · Glendale, CA · +25 more sites

RecruitingNot applicableNCT07349706

IMST for Dementia Risk Reduction

Sponsor: Florida State University

Tallahassee, FL

RecruitingPhase 3NCT07412756

A Study of Brenipatide in Adult Participants With Major Depressive Disorder

Sponsor: Eli Lilly and Company

Moorpark, CA · Orange, CA · New Haven, CT · +29 more sites

RecruitingPhase not listedNCT00024635

Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

Sponsor: National Institute of Mental Health (NIMH)

Bethesda, MD

RecruitingNot applicableNCT05491538

Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness

Sponsor: VA Office of Research and Development

Minneapolis, MN

RecruitingNot applicableNCT06038929

Effect of Vagal Nerve Stimulation on Gastric Motor Functions

Sponsor: Mayo Clinic

Minneapolis, MN · Rochester, MN

RecruitingPhase 1NCT06767566

Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery

Sponsor: University of Utah

Pittsburgh, PA · Salt Lake City, UT

RecruitingNot applicableNCT07475845

Teenthrive 2: Treatments for Improving Mood in Teens

Sponsor: Butler Hospital

Boston, MA · Columbus, OH

RecruitingPhase not listedNCT04877977

Long-term Observation of Participants With Mood Disorders

Sponsor: National Institute of Mental Health (NIMH)

Bethesda, MD

RecruitingPhase not listedNCT06462196

Natural History of Depression, Bipolar Disorder and Suicide Risk

Sponsor: National Institute of Mental Health (NIMH)

Bethesda, MD

RecruitingPhase 3NCT07573176

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

Sponsor: Janssen Research & Development, LLC

Bryant, AR · Bellflower, CA · Glendale, CA · +31 more sites

RecruitingNot applicableNCT05991713

Geolocation Positional System (GPS) Experience

Sponsor: University of Miami

Coral Gables, FL

RecruitingNot applicableNCT06906302

RISE Versus Advocacy-based Enhanced Care as Usual for Patients Experiencing IPV

Sponsor: Boston University

Boston, MA · Minneapolis, MN · Philadelphia, PA

RecruitingNot applicableNCT07218250

A Study of a One-Time Counseling Session to Help Reduce Depression, Anxiety, and Distress in People With Cancer

Sponsor: Memorial Sloan Kettering Cancer Center

Basking Ridge, NJ · Middletown, NJ · Montvale, NJ · +4 more sites

RecruitingNot applicableNCT06206226

The Oh Happy Day Class - Digital Connections (OHDC-DC): A Pilot Study

Sponsor: University of Wisconsin, Madison

Madison, WI

Related conditions

Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.