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RecruitingEarly Phase 1

Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

Sympathetic Neural Patterns and Transduction in Obesity-associated Hypertension

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 55 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: Infusions

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how nerves tell blood vessels to raise blood pressure during stress, and how obesity and high blood pressure affect this. It is for adults ages 18–55 with or without obesity or high blood pressure. Researchers will measure nerve activity and blood flow during exercise, low oxygen levels, and drugs given into a vein that widen or narrow blood vessels.

The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • All groups: Ages 18–55. BMI is a measure of body size based on height and weight.
  • Control group: BMI below 30.
  • High blood pressure group: BMI below 30 and high blood pressure confirmed by a monitor worn for 24 hours.
  • Obesity group: BMI above 30.
  • Obesity and high blood pressure group: BMI above 30 and high blood pressure confirmed by a monitor worn for 24 hours.

Who can't join

  • For all groups: Other serious heart or blood vessel disease.
  • Kidney disease.
  • A history of smoking.
  • Diabetes.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Control - BMI\<30, age 18-55 * Hypertensive - BMI\<30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Obese- BMI\>30, age 18-55 Obese-hypertensive- BMI\>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Exclusion Criteria: All groups - presence of other significant cardiovascular disease, renal disease, history of smoking, diabetes,

Study sites (1)

TX