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Late Onset Alzheimer's Disease

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
55 Years and older
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how genes affect the risk of Alzheimer's disease (AD). It seeks families and people from any ethnic background who have a family history of AD, whether or not they have the disease. It also includes some people with related brain disorders.

The goal of this study is to is to focus on the genetic influences on Alzheimer's Disease (AD) risk. The investigators are looking for families and/or individuals (affected or unaffected) of any ethic background (African American, Caucasian, and Hispanics) with a family history of AD and willing to participate.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Have a diagnosis of definite or likely AD, or a related brain disorder such as frontotemporal dementia (FTD) or Lewy body dementia (LBD). FTD and LBD cases without a family history may also be included.
  • Have a living brother or sister with likely or possible AD.
  • Have a third living relative who developed AD at age 50 or older, or who does not have AD and is age 60 or older.
  • If you are in the same generation as the family's main study participant, have a companion who can share information about you.
  • Be able to agree to join the study, or have someone authorized to agree for you.

Who can't join

  • Have no suitable person who can share information about you.
  • Have an uncertain diagnosis of AD or a related disorder.
  • Have another diagnosis that could explain your symptoms.
  • Do not want to join the study.
  • Have no living brother or sister with AD or a related disorder, unless you have FTD or LBD without a family history.
  • Cannot agree to join the study and have no authorized person or close family member to agree for you.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Established diagnosis of definite or probable AD or have a diagnosis of a related neurodegenerative disorder such as Frontotemporal Dementia (FTD) or Lewy Body Dementia (LBD) (will also recruit sporadic FTD and LBD) cases. * a living sibling with probable or possible AD; * a third living relative affected with AD (onset age 50 or older) or unaffected (60 or older); * participants in the proband's generation with an identified companion serving as an informant; * participants who have capacity to consent or participants lacking capacity to consent with a surrogate/proxy in place to provide consent. Exclusion Criteria: * failure to identify an appropriate informant; * uncertainty of the clinical diagnosis of Alzheimer's disease or other related disorder; * discovery of additional diagnosis that could account for the clinical manifestations; * unwillingness to participate; * failure to identify a living sibling with AD or other related disorder (except in the cases of sporadic FTD and sporadic LBD); * participants lacking the capacity to consent who do not have a surrogate or proxy or next of kin to provide consent.

Study sites (12)

DC

FL

IL

IN

MN

MO

NC

NY

PA

TX

WA