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Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction

Effect of Beta-blocker Discontinuation on Functional Capacity and Cardiac Hemodynamics in Patients With Heart Failure With Preserved Ejection Fraction

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
50 Years to 80 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Visits mentioned: 2 visits
  • Procedures mentioned: Questionnaires

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "The study involves 2 visits that are 4 weeks apart."
  • "The first study visit will occur at a standard of care clinic visit and the second visit will be a research visit to fill out questionnaires and perform the limited echocardiogram."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This small study tests what changes after people stop taking beta-blockers, a type of heart medicine. It will study 30 people with heart failure whose hearts still pump out a normal share of blood, comparing results before stopping and 4 weeks later.

This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are 50 to 80 years old.
  • Your heart failure is stable, with symptoms that limit everyday activity (NYHA Class II–III) or a BNP blood test level of at least 100. BNP is a sign of heart strain.
  • A heart ultrasound shows that your heart pumps out at least 50% of its blood with each beat.
  • The ultrasound shows Grade 2 or 3 problems with your heart relaxing and filling with blood.
  • You regularly take a loop diuretic, a water pill that removes extra fluid.
  • You currently take a beta-blocker.

Who can't join

  • Your beta-blocker was prescribed for another heart problem, such as an irregular heartbeat called atrial fibrillation or disease in the arteries that supply your heart.
  • Your heart rate is over 100 beats per minute.
  • You were hospitalized for heart failure within the past 3 months.
  • You do not speak English.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Stable HFpEF patients with NYHA Class II-III or elevated BNP ≥100 * N=30 (Target: 30). * Age: 50 \~ 80 years. * ECHO evidence of EF ≥50% and Grade 2 or 3 diastolic dysfunction. * Chronic loop diuretic use * Currently on beta-blocker Exclusion Criteria: * Beta blocker was prescribed for treating other cardiac conditions such as atrial fibrillation or coronary artery disease. * Heart rate \> 100 bpm * Recent hospitalization due to HF within 3 months * Non-English speaker

Study sites (1)

CT