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Exercise Training and Fat Metabolism in Postmenopausal Women

Resistance Training Modulation of Fat Metabolism in Obese Postmenopausal Women

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
50 Years to 75 Years
Sex
Female only
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Time periods mentioned: 12 weeks
  • Procedures mentioned: Biopsies

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Additionally, at weeks 4 and 12 participants will come to the lab for adipose tissue biopsies of the abdominal and gluteal adipose tissue for determination of adipogenesis and lipogenesis using stable-isotope-labeled water they will drink daily over this eight-week labeling period."
  • "The sample size for these studies will consist of 120 participants that will be randomly assigned via computer randomization to either resistance training (n=60) or endurance training (n=60) for 12 weeks."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: * Women * Postmenopausal (50-75 yrs.) * Obese (BMI 30-50 kg/m2) * Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL) * Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a week) * Non-smokers * No hormone replacement therapy for at least the past two years. Exclusion Criteria: * Engaging in purposeful resistance training or endurance training (\> 20min/day, \> 2 days/week) * Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic * Type 1 or type 2 diabetes * Medical problems in which exercise is contraindicated, such as chronic infections * History of, or currently presentation with, cancer, cardiovascular or respiratory disease * Uncontrolled thyroid dysfunction, liver or renal dysfunction * Taking any medication affecting lipid metabolism * Musculoskeletal disease or injury that would otherwise prevent engagement in resistance and endurance training * Smokers and those with diagnosed eating disorders

Study sites (1)

FL