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GI Oxalate Absorption

Determine the Contribution of Paracellular GI Oxalate Absorption in Obese and Roux-en-Y Gastric Bypass Kidney Stone Patients

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 70 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Time periods mentioned: 4 years, 3 days
  • Procedures mentioned: Urine samples

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "They will also collect 24-hour urine samples at home on Days 4 and 5."
  • "Study Population and Recruitment Enroll 10 post-Roux-en-Y Gastric Bypass stone forming, 10 obese stone forming, and 10 non-obese stone forming participants over four years of the award."
  • "Experimental Design and Implications Administration of very low oxalate diet (50mg/day) for three days followed by 13c2-oxalate and sucralose oral load test will determine the amount of oxalate absorbed via gastrointestinal (GI) paracellular pathways discriminated from endogenous oxalate production."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

This study aims to learn more about how oxalate, a compound found in many foods, may affect a person's chances of forming kidney stones. Active participation in this study will last for around one week. For the first two days, subjects will be asked to eat a special diet at home. From Days 3-5, they will eat special meals delivered to their home from a research clinic at the University of Chicago. They will also collect 24-hour urine samples at home on Days 4 and 5. On Day 6, they will come in to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. They will receive a special liquid that contains oxalate, and we will have them eat a specially prepared breakfast that is low in oxalate and citrate.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: Post-Roux-en-Y gastric bypass stone formers: * Age 18-70 * Previous history of Roux-en-Y gastric bypass * History of at least one calcium-based kidney stone after surgery * Pre-protocol urine oxalate above the lab normal range (50mg/day) Obese stone formers: * Age 18-70 * Body mass index (BMI) \>=30kg/m2 * History of at least one calcium-based kidney stone * Pre-protocol urine oxalate above the lab normal range (50mg/day) Non-obese stone formers: * Age 18-70, BMI between 18.5-29.9 kg/m2 * History of at least one calcium-based kidney stone Exclusion Criteria: Post-Roux-en-Y gastric bypass stone formers: * History of colon resection (partial or complete) * History of duodenal switch bowel surgery * History of ileal-jejunal bypass surgery * History of primarily uric acid, cysteine, or struvite stones Obese and non-obese stone formers: * History of bowel surgery * History of colon resection * History of inflammatory bowel disease (Crohn's disease, Ulcerative Colitis) * History of primarily uric acid, cysteine, or struvite stones

Study sites (1)

IL