Modulating Exercise Dosage to Improve Concussion Recovery
Modulating Exercise Dosage to Improve Concussion Recovery: A Randomized Clinical Trial
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 13 Years to 18 Years
- Sex
- All sexes
- Healthy volunteers
- Not accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
In plain language
This study tests whether more aerobic exercise, at a safe level set for each person, helps teens recover faster from a concussion. The program starts within 21 days of the injury. It also looks at changes in how the body works and whether exercise reduces later health problems.
Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whether exercise can prevent the development of secondary sequelae. Our objective is to examine if a high dose exercise program (higher volume than currently prescribed at an individualized, safe intensity level) initiated within 21 days of concussion results in faster symptom resolution, altered physiological function, or reduced secondary sequalae. Findings from this research will lead to more rigorous and precise rehabilitation guidelines and improved understanding about how exercise affects neurophysiological function among adolescents with concussion.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Who can join
- Age 13 to 18.
- A score above 10 on the Post-Concussion Symptom Scale, a checklist that measures symptoms, showing you have not yet recovered.
- A concussion diagnosed by a sports medicine doctor.
Who can't join
- An existing disorder of the brain or nerves.
- A health reason that makes exercise unsafe.
- Another concussion within 6 months before joining the study, not counting the current injury.
Simplified for readability. The official criteria below are what the study team uses.
Official eligibility criteria
Inclusion Criteria: * 13-18 years of age * Post-Concussion Symptom Scale (PCSS) score \>10 to ensure participants are not recovered by enrollment * Concussion diagnosis by a sports medicine physician Exclusion Criteria: * Pre-existing neurological disorders * Exercise contraindications * Concussion \<6 months before enrollment (excluding the current injury)
Study sites (3)
CO
- University of Colorado Denver · Aurora, CO 80045David R Howell, PhD · Study contact · 7207771502 · ConcussionResearch@cuanschutz.eduKelsie Richardson, MS · Study contact · 7207771502 · ConcussionResearch@cuanschutz.eduMore trials in Aurora
MA
- Boston Children's Hospital · Boston, MA 02115Danielle Hunt, MS · Study contactWilliam P Meehan III, MD · Principal investigatorMore trials in Boston
- Spaulding Rehabilitation Hospital · Cambridge, MA 02138Andrew Taylor, PhD · Study contactJ Andrew Taylor, PhD · Principal investigatorMore trials in Cambridge