RightFit
RecruitingPhase not listed

Imaging the Pathogenesis of Cerebral Small Vessel Disease

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not stated
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI."
  • "The goal of this study it to recruit and follow individuals at risk for WMH progression and use serial MRI scanning to gain insights into the pathogenesis of CSVD."
  • "The hallmark of CSVD is white matter hyperintensities (WMH) seen on T2-weighted MRI."
  • "We will follow 50 patients with 3 MRIs performed over 1.25 years"
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study uses repeated MRI scans to learn how disease in the brain’s small blood vessels develops. It is for people with signs of a stroke caused by blocked blood flow, a risk factor for blood vessel disease, and signs of small blood vessel disease on MRI.

Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use serial MRI scanning to gain insights into the pathogenesis of CSVD.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Signs of a stroke caused by blocked blood flow, found by a medical exam or a scan.
  • At least one risk factor: high blood pressure, high cholesterol, or diabetes.
  • An MRI showing disease in the brain’s small blood vessels.

Who can't join

  • Unable to complete 3 research MRI scans over 15 months.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Clinical or radiographic evidence of ischemic stroke * One vascular risk factor (hypertension, hyperlipidemia, or diabetes) * Evidence of cerebral small vessel disease on MRI Exclusion Criteria: * Inability to complete 3 research MRI scans over 1.25 years

Study sites (1)

MD