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Cognitive Decline Following Deep Brain Stimulation

A Neural Basis for Cognitive Decline Following Deep Brain Stimulation

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Visits mentioned: 4 visits
  • Procedures mentioned: MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS)."
  • "Participants will undergo four visits, including a 1-hour screening visit, a 1.5-hour pre-DBS MRI scanning visit, and a 3.5-hour post-DBS cognitive assessment visit."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks for signs in MRI brain scans that may predict changes in thinking and memory after deep brain stimulation (DBS), a treatment that uses electrical signals in the brain. It is for adults with Parkinson's disease who plan to have DBS surgery and adults without Parkinson's disease for comparison.

This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS. A total of 55 participants with Parkinson's Disease planning to undergo DBS will be recruited from MUSCs Clinical DBS Program. Participants will undergo four visits, including a 1-hour screening visit, a 1.5-hour pre-DBS MRI scanning visit, and a 3.5-hour post-DBS cognitive assessment visit. In addition control participants without Parkinson's Disease will be recruited to undergo MRI scanning and cognitive assessments.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • All participants: Must be older than 18.
  • Parkinson's group: Must plan to have DBS surgery as part of their regular care.
  • Comparison group: Must be about the same age as participants in the Parkinson's group.

Who can't join

  • All participants: Vision or hearing problems that have not been corrected.
  • All participants: Pregnant or expecting to become pregnant during the study.
  • All participants: Fear of tight spaces, or being unable to lie on their back in the MRI scanner.
  • All participants: COPD, a long-term lung disease, that requires oxygen use.
  • All participants: Metal implants that are not safe for MRI, such as some surgical clips, staples, or heart pacemakers.
  • Comparison group only: Parkinson's disease or another movement disorder.
  • Comparison group only: Untreated conditions affecting mental health or brain function.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

PD Participants Inclusion Criteria: * Subjects above 18 years of age * Subjects who will undergo DBS surgery as part of their clinical care for PD Exclusion Criteria: * Uncorrected visual or hearing impairments, as indicated by self-report * Individuals who are pregnant or expect to become pregnant during the course of the study * Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner * COPD with oxygen dependence * Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.) Non-PD Control Participants Inclusion Criteria: * Subjects above 18 years of age * Age matched to participants in PD group Exclusion Criteria: * Diagnosis of Parkinsons Disease or other movement disorder * Untreated neuropsychiatric disorders * Uncorrected visual or hearing impairments, as indicated by self-report * Individuals who are pregnant or expect to become pregnant during the course of the study * Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner * COPD with oxygen dependence * Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)

Study sites (1)

SC