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Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2

Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2 Infection and Inflammation in Human Adipose Tissue

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 80 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

The investigators are studying the pathophysiologic links between obesity, insulin resistance (IR), adipose tissue infection, and post-acute sequelae of COVID-19 (PASC). This study looks at whether adipose (fat) tissue contributes to PASC by driving chronic inflammation or by serving as a reservoir for SARS-CoV-2 persistence. The results will not only determine whether obesity and IR are risk factors for PASC, but will also define fundamental biology that sets the stage for the investigation of novel or existing therapies that target the causal pathways identified.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: * Ages 18 to 80 * BMI ≥ 25 kg/m2 * not currently pregnant Exclusion Criteria: Arm 2 (Adipose Tissue Biopsy) exclusions include * pregnancy * prior liposuction * recent change in weight (\> 2 kg in one month) * bleeding disorders * anticoagulant use Arm 3 (healthy controls only) exclusions include patients with * major organ disease * diabetes * history of liposuction * bariatric surgery * eating disorders * psychiatric disorders * pregnancy or lactation * recent change in weight (over the past 12 weeks), * use of weight loss medication or oral steroids * hematocrit \< 33% * fasting glucose \>= 126 mg/dL * blood pressure \>160/100 mmHg

Study sites (2)

CA