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Exercise Response in Humans With Obesity

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
20 Years to 45 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how long-term inflammation affects muscles and how they respond to exercise. It is for men and women with obesity who are 20 to 45 years old.

This study is being done to understand how chronic inflammation affects muscle function and responses to exercise.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Men and women with obesity, ages 20 to 45.

Who can't join

  • Diabetes or fasting blood sugar above 126 mg/dL.
  • Anemia (low red blood cells), with hemoglobin below 11 g/dL for women or 12 g/dL for men; a history of blood clotting problems; or taking warfarin-type blood thinners.
  • Active disease in the heart’s blood vessels or a history of unstable major blood vessel disease. This includes unstable chest pain, heart attack, stroke, or a procedure to restore blood flow in heart, limb, or neck arteries within 3 months of joining.
  • Kidney failure, with blood creatinine above 1.5 mg/dL; or ongoing active liver disease, with liver tests AST above 144 IU/L or ALT above 165 IU/L.
  • Smoking, drinking more than 2 glasses of alcohol a day, or other substance abuse.
  • Pregnancy or breastfeeding.
  • An underactive thyroid that is untreated or not controlled.
  • A long-term illness that greatly limits daily life, as judged by the study team.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Obese men and women ≥ 20 and ≤ 45 years of age. Exclusion Criteria: * Diabetes or fasting plasma glucose \>126 mg/dL * Anemia (female subjects hemoglobin of \<11 g/dl and male subjects hemoglobin \<12 g/dl) * Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment) * Renal failure (serum creatinine \> 1.5mg/dl) * Chronic active liver disease defined as aspartate aminotransferase (AST)\>144 IU/L or alanine transaminase (ALT) \>165 IU/L) * Oral warfarin group medications or history of blood clotting disorders. * Smoking * Pregnancy or breastfeeding * Alcohol consumption greater than 2 glasses/day or other substance abuse * Untreated or uncontrolled hypothyroidism * Debilitating chronic disease (at the discretion of the investigators)

Study sites (1)

MN