RightFit
RecruitingNot applicable

Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
Up to 80 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how obesity and lasting symptoms after COVID-19 affect older Veterans’ physical abilities, quality of life, and fat tissue. It also tests whether diet changes and exercise help Veterans with obesity lose weight, reduce inflammation and cell aging, and recover from lasting COVID-19 symptoms.

The research in this VA Merit will examine the effects of obesity and Post-COVID Conditions (PCC) on physical functioning, health-related quality of life, and adipose tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will evaluate whether a weight loss intervention, including dietary modification and exercise, in obese Veterans with and without PCC will reduce systemic and adipose tissue inflammation and senescence and promote PCC recovery.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are a U.S. Veteran.
  • If you have no lasting COVID-19 symptoms, you report never having COVID-19 or having it more than 90 days ago.
  • If you have lasting COVID-19 symptoms, you have a documented COVID-19 infection and at least one symptom lasting more than 4 weeks.
  • Your body mass index (BMI), a measure based on height and weight, is 19–25 or 30–50.

Who can't join

  • You have a nerve, brain, muscle, bone, or other condition that keeps you from completing the study’s physical tests.
  • You have an active illness involving inflammation, COVID-19 or another infection, the immune system attacking the body, the digestive system, cancer, or mental health.
  • You have active liver disease with liver blood tests more than 2.5 times the normal limit, or kidney disease with a kidney filtering score below 45.
  • Your diabetes is not controlled: your HbA1c (a measure of blood sugar over time) is above 10%, or you currently use insulin.
  • Your weight changed by more than 5 kilograms (about 11 pounds) in the past month.
  • You report alcohol or drug abuse.
  • You take blood-thinning medicine.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: 1. U.S. Veteran 2. Self-reported COVID-19 naïve or COVID-19 \> 90 days ago for lean and obese PCC naïve or documented COVID-19 for the lean and obese PCC groups (At least one PCC symptom \>4 weeks) 3. Body Mass Index: 19-25 or 30-50 kg/m2 Exclusion Criteria: 1. Neurologic, musculoskeletal, or other condition that limits subject's ability to complete study physical assessments 2. Active inflammatory, COVID-19, autoimmune, infectious, hepatic (LFTs \> 2.5 x WNL), renal (eGFR\<45), gastrointestinal, malignant, and psychiatric disease 3. Uncontrolled diabetes (HbA1c \>10% or the current use of insulin) 4. Weight change within the past month of \>5 kg 5. Self-reported alcohol or drug abuse 6. Anti-coagulant medication usage

Study sites (2)

MD

TX