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Impact of Yo-Yo Sleep on Cardiometabolic Health

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 49 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Mentioned in the study description

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Mentioned in the study description
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This 4-week study is for adults ages 18 to 49. It tests how sleeping less for 5 days and longer for 2 days, compared with getting enough sleep each night, affects calories taken in and used, heart health, and blood sugar health. It also tests whether keeping sleep timing steady is better than shifting it 2 hours later.

The goal of this clinical trial is to test the impact of repeated intermittent short sleep, with short sleep maintained 5 days per week followed by 2 days of prolonged sleep, compared to daily adequate sleep, on energy balance and cardiometabolic risk. A secondary goal of this research is to determine if maintaining a constant midpoint of sleep while undergoing intermittent short sleep, leads to better outcomes than intermittent short sleep with a 2-hour delay in sleep midpoint. The aims of this research will be tested in the context of a 3-group, parallel-arm, outpatient intervention of 4 weeks in duration, in young-to-middle-aged adults (aged 18-49 years).

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are 18 to 49 years old.
  • Your BMI is 20 to 29.9. BMI is a measure of weight compared with height.
  • You usually sleep 7 to 9 hours a night without sleep aids or naps.

Who can't join

  • You have a sleep disorder.
  • You have a mental health disorder, including an eating disorder or depression linked to the seasons.
  • You are pregnant, were pregnant in the past year, or are breastfeeding.
  • You smoke cigarettes or quit less than 3 years ago.
  • You have diabetes, have high blood pressure, or take beta-blockers, a type of heart and blood pressure medicine.
  • You take medicines that prevent blood clots, called anticoagulants or antiplatelets.
  • Your weight changed recently, you are in a weight loss program, or you have ever had weight loss surgery or another weight loss or digestive tract procedure.
  • You travel across time zones or work shifts outside traditional hours.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Aged 18 to 49 years * BMI 20-29.9 kg/m2 * Habitually sleeping 7-9 hours/night without sleep aids or naps Exclusion Criteria: * Sleep disorders * Psychiatric disorders (including eating disorders) and seasonal affective disorder * Pregnancy (current/prior year) * Breastfeeding * Smokers (Any cigarette smoking or ex-smokers \<3years) * Diabetes * Elevated blood pressure, taking beta-blockers * Individuals taking anti-coagulants or anti-platelets * Recent weight change or participation in a weight loss program or have ever had bariatric surgery or other weight loss or gastrointestinal procedure. * Travel across time zones; shift work (non-traditional hours)

Study sites (1)

NY