Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
The Role of Circulating Meta-Inflammatory Monocytes in Adolescent Insulin Resistance
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 14 Years to 18 Years
- Sex
- All sexes
- Healthy volunteers
- Accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
In plain language
This study collects health information and blood samples from teens ages 14 to 18. It looks at how body makeup, daily habits, and diet affect immune cells called MiMos, which may make it harder for the body to use insulin to control blood sugar.
This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced MiMo related activities leading to insulin resistance.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Who can join
- You are 14 to 18 years old.
- You are in a late stage of puberty (Tanner stage 4 or 5).
- You meet a listed weight or pre-diabetes range: normal weight (BMI from the 5th to below the 85th percentile), overweight (above the 86th to below the 94th percentile), obesity (95th percentile or higher), or pre-diabetes (HbA1c above 5.7%). BMI compares weight with height; percentiles compare teens of the same age and sex. HbA1c measures average blood sugar.
- For the type 2 diabetes group, you have been diagnosed with type 2 diabetes.
Who can't join
- You are pregnant.
- You take medicines that affect how your body handles blood sugar, unless prescribed to manage type 2 diabetes. Examples include medicines that lower immune system activity, cancer medicines, or high-dose steroids.
- You have been diagnosed with an autoimmune disease (when the immune system attacks the body), cancer, or a disability affecting thinking or perception that would prevent you from following study staff directions.
- You have an allergy to, or cannot tolerate, milk, soy, or palm oil.
Simplified for readability. The official criteria below are what the study team uses.
Official eligibility criteria
Inclusion Criteria: * Between 14 and 18 years of age * Tanner stage 4 or 5 (mature adult stage of puberty) * Normal weight (BMI ≥ 5th percentile \& \< 85th percentile), overweight (BMI \> 86th percentile) \& \< 94th percentile), obese weight (BMI percentile ≥ 95th percentile), and/or pre-diabetes (HbA1c \> 5.7%) * For Type 2 Diabetes cohort, diagnosis of Type 2 Diabetes Exclusion Criteria: * Currently pregnant * Use medications known to affect glucose metabolism (immunosuppressive medications, cancer medications, or high dose steroids), unless prescribed for Type 2 Diabetes management * Prior diagnosis of autoimmune disease, cancer, or a cognitive or perceptual disability that would inhibit following directions of study staff * Allergies or intolerance to milk, soy, or palm oil
Study sites (1)
MI
- University of Michigan · Ann Arbor, MI 48109More trials in Ann Arbor