RightFit
RecruitingPhase 4

Personalized Real-Time DBS and PD Mechanisms

Identifying Circuit Dynamics Underlying Motor Dysfunction in Parkinson's Disease Using Real-Time Neural Control

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 80 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Combining electrophysiological data with high-resolution (7T) magnetic resonance (MR) imaging and computational modeling, the investigators will examine which specific neuronal pathways connected with the STN need to be activated to evoke frequency-specific neural responses in the STN and MC (SA3)."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how certain brain signals relate to movement problems in Parkinson’s disease. It uses brain stimulation, the medicine levodopa, and computer models to help guide future treatments that adjust to each person’s brain signals in real time. It is for people already scheduled for deep brain stimulation (DBS) surgery as part of their usual care.

A prospective cohort of patients scheduled to undergo deep brain stimulation (DBS) implantation surgery for the treatment of Parkinson's disease as per standard of care will be invited to participate in this study. This mechanistic study is aimed at better understanding the role of basal ganglia beta band (11-35 Hz) oscillations and resonance in the manifestation of Parkinson's disease (PD) motor signs using closed-loop electrical neurostimulation, levodopa medication, and computational modeling. The ultimate goal of this study is to inform the development of closed-loop neuromodulation technology that can be programmed and adjusted in real time based on patient-specific neural activity.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You can understand the study and agree to take part.
  • You have been diagnosed with idiopathic Parkinson’s disease, meaning its cause is unknown.
  • Your care team has decided you qualify for DBS surgery aimed at a brain area called the subthalamic nucleus.
  • You can handle delays in taking your daily Parkinson’s medicines.

Who can't join

  • You have Parkinson-like symptoms caused by another condition, a stroke, or another disease of the brain or spinal cord that gets worse over time.
  • The study team believes you have a condition that could greatly affect your safety, your ability to follow study steps, or the study results.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Key Inclusion Criteria: * Ability to provide informed consent. * Clinical diagnosis of idiopathic Parkinson's disease. * Determined, as per standard of care, to be a candidate for deep brain stimulation (DBS) surgery targeting the subthalamic nucleus. * Ability to tolerate delays in taking daily standard Parkinson's disease medications. Key Exclusion Criteria: * Secondary Parkinsonism, stroke, or progressive central nervous system disease other than Parkinson's disease. * Patient has a condition that, in the opinion of the investigators, would significantly increase the risk of interfering with study compliance, safety, or outcome.

Study sites (1)

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