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Alendronate for Osteonecrosis in Adults With Sickle Cell Disease

A Feasibility Study of Alendronate as Treatment for Osteonecrosis in Adults With Sickle Cell Disease

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 80 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests alendronate taken by mouth in adults with sickle cell disease and osteonecrosis. Osteonecrosis means bone tissue has died because it did not get enough blood. Everyone in the study receives alendronate.

A prospective, single-arm, intervention study of oral alendronate in adults with sickle cell disease and osteonecrosis

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Be 18–80 years old and have any type of sickle cell disease, confirmed by a blood test.
  • Be able to give written consent to join the study.
  • Be able to lie on a DXA scanner, a machine that uses X-rays to measure bone strength.
  • Have a negative urine pregnancy test when joining if you could become pregnant.

Who can't join

  • Are pregnant.
  • Are an adult who cannot give consent.
  • Are not yet an adult.
  • Are a prisoner.
  • Have been hospitalized for any reason within 2 weeks before joining the study.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Age 18-80 years with SCD (any genotype, confirmed by hemoglobin electrophoresis or high performance liquid chromatography) * Ability to provide written informed consent * Ability to lay on a dual-energy X-ray absorptiometry (DXA) scanner * Negative urine pregnancy test for anyone of childbearing potential at study entry Exclusion Criteria: * Pregnant women * Adults unable to consent * Individuals who are not yet adults (infants, children, teenagers) * Prisoners * Hospitalizations (for any cause) within 2 weeks of study entry

Study sites (1)

CA