Sickle Cell Disease clinical trials

127 recruiting studies in the US for sickle cell disease, an inherited red blood cell disorder.

Sickle cell disease research covers Phase 1 and combined Phase 1/2 studies of gene and cell therapies, Phase 2 medicines for pain crises, and studies of care and quality of life. Gene therapy trials typically involve a long commitment and treatment at specialized centers. Studies often ask how many pain crises you've had in the past year.

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By phase

Showing 40 of 127 studies

RecruitingPhase 1 / Phase 2NCT04774536

Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease

Sponsor: Mark Walters, MD

Davis, CA · Los Angeles, CA · Oakland, CA

RecruitingPhase 1 / Phase 2NCT06546670

A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease

Sponsor: Novartis Pharmaceuticals

Birmingham, AL · Miami, FL · Boston, MA · +6 more sites

RecruitingPhase 1NCT07566494

Escalating Doses of VAS-101 in Subjects With Stable Sickle Cell Disease

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Bethesda, MD

RecruitingPhase not listedNCT05213572

Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Bethesda, MD

RecruitingPhase not listedNCT00542230

Blood Sampling for Research Related to Sickle Cell Disease

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Bethesda, MD

RecruitingNot applicableNCT07674277

Virtual Reality for SCD VOC

Sponsor: University of Maryland, Baltimore

Baltimore, MD

RecruitingPhase 3NCT06439082

A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)

Sponsor: Novartis Pharmaceuticals

Birmingham, AL · Orange, CA · Washington D.C., DC · +14 more sites

RecruitingPhase 1NCT06506461

Gene Editing For Sickle Cell Disease

Sponsor: St. Jude Children's Research Hospital

Memphis, TN

RecruitingPhase 3NCT06975865

The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease

Sponsor: Sanofi

Birmingham, AL · Phoenix, AZ · Clovis, CA · +18 more sites

RecruitingPhase 1 / Phase 2NCT07599176

Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Bethesda, MD

RecruitingPhase 1NCT05904093

Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Bethesda, MD

RecruitingNot applicableNCT06374238

Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

Sponsor: University of Pittsburgh

Mobile, AL · Los Angeles, CA · Hartford, CT · +11 more sites

RecruitingPhase 2NCT06699849

Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis

Sponsor: CSL Behring

Oakland, CA · Orange, CA · Washington D.C., DC · +17 more sites

RecruitingPhase not listedNCT06071377

Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)

Sponsor: National Alliance for Sickle Cell Centers

Birmingham, AL · Wilmington, DE · Indianapolis, IN · +5 more sites

RecruitingPhase 1NCT07187973

A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)

Sponsor: Disc Medicine, Inc

Birmingham, AL · San Francisco, CA · Atlanta, GA · +8 more sites

RecruitingPhase not listedNCT03937817

Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Bethesda, MD

RecruitingNot applicableNCT05359991

Exercise in Child Health

Sponsor: University of California, Irvine

Irvine, CA

RecruitingPhase 1NCT04055818

A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease

Sponsor: EpiDestiny, Inc.

Chicago, IL

RecruitingEarly Phase 1NCT06313398

Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Bethesda, MD

RecruitingPhase 3NCT07656415

A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)

Sponsor: Agios Pharmaceuticals, Inc.

Indianapolis, IN · Grand Rapids, MI · Flowood, MS

RecruitingPhase not listedNCT05170412

Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease

Sponsor: National Institutes of Health Clinical Center (CC)

Bethesda, MD

RecruitingPhase 3NCT06609226

A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia

Sponsor: Novo Nordisk A/S

Birmingham, AL · Phoenix, AZ · Los Angeles, CA · +36 more sites

RecruitingPhase 3NCT06612268

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

Sponsor: Novo Nordisk A/S

Birmingham, AL · Mobile, AL · Phoenix, AZ · +47 more sites

RecruitingPhase not listedNCT00081523

Natural History of Sickle Cell Disease

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Washington D.C., DC · Bethesda, MD

RecruitingPhase 2NCT05640271

Tocilizumab for Acute Chest Syndrome

Sponsor: University of Chicago

Chicago, IL

RecruitingPhase not listedNCT02824471

Sickle Cell Disease Biofluid Chip Technology (SCD BioChip)

Sponsor: University Hospitals Cleveland Medical Center

Cleveland, OH

RecruitingPhase not listedNCT06944067

Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease

Sponsor: National Human Genome Research Institute (NHGRI)

Bethesda, MD

RecruitingNot applicableNCT07562451

Assessing Molecular Mechanisms and Effects of Music Therapy in Youth With Sickle Cell Disease Using Single-cell RNA-sequencing

Sponsor: Emory University

Atlanta, GA

RecruitingPhase 2NCT07023666

Early Screening and Treatment of Heart Complication in Sickle Cell Disease

Sponsor: Inova Health Care Services

Fairfax, VA · Falls Church, VA

RecruitingPhase 1NCT07226219

Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease

Sponsor: St. Jude Children's Research Hospital

Memphis, TN

RecruitingPhase 1NCT06442761

SCD Stem Cell Mobilization and Apheresis Using Motixafortide

Sponsor: St. Jude Children's Research Hospital

Birmingham, AL · Bethesda, MD · Memphis, TN

RecruitingPhase 2NCT07369024

Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults

Sponsor: Mohsen Saidinejad

Torrance, CA

RecruitingNot applicableNCT07776444

Cerebrovascular Reactivity Measurements With High-Density Diffuse Optical Tomography

Sponsor: Washington University School of Medicine

St Louis, MO

RecruitingPhase 2 / Phase 3NCT05431088

A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD

Sponsor: Pfizer

Mobile, AL · Hartford, CT · New Haven, CT · +43 more sites

RecruitingPhase 1 / Phase 2NCT06481306

A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

Sponsor: Bristol-Myers Squibb

Birmingham, AL · La Jolla, CA · Oakland, CA · +16 more sites

RecruitingPhase not listedNCT03685721

Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Bethesda, MD

RecruitingPhase not listedNCT04398628

ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders

Sponsor: American Thrombosis and Hemostasis Network

Phoenix, AZ · Little Rock, AR · Los Angeles, CA · +73 more sites

RecruitingPhase 1 / Phase 2NCT03653338

T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias

Sponsor: Paul Szabolcs

Pittsburgh, PA

RecruitingNot applicableNCT06725550

Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0

Sponsor: University of Cincinnati

Cincinnati, OH

RecruitingPhase not listedNCT05810181

Gene Therapy Communication: Use of a Needs Assessment to Drive Decision-AIDS for Gene Therapy for Rare Diseases (GENETX)

Sponsor: St. Jude Children's Research Hospital

Memphis, TN

Related conditions

Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.