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AM vs PM Exercise Training

Effects of AM vs. PM Exercise Training on Blood Pressure and Vascular Health in Postmenopausal Females With Hypertension

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
55 Years to 80 Years
Sex
Female only
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests how morning exercise and early evening exercise affect blood pressure and blood vessel health. It is for women ages 55–80 who have high blood pressure and have gone through menopause.

The treatment of high blood pressure, or hypertension, is multifaceted and can include pharmacological therapies (i.e., medications) and lifestyle modifications such as physical activity. Chronotherapy, which describes timing of a treatment with the body's daily rhythms, has recently been used with hypertension medications and has been shown to be effective at lowering blood pressure and reducing the risk of cardiovascular disease events. Specifically, taking medications in the evening was shown to be more effective than morning medication routines. Little information is available about the effectiveness of chronotherapy combined with exercise (i.e., planned physical activity) interventions in older adults with hypertension. The purpose of this study is to examine how exercise training performed in the morning and early evening affects blood pressure and other measures of blood vessel health in postmenopausal females with hypertension.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are 55–80 years old.
  • You are female and have gone through menopause, meaning your monthly periods have ended.
  • Your top blood pressure number is at least 130 without blood pressure medicine, or above 120 with medicine. Your bottom number is at least 80.
  • You can walk without help.

Who can't join

  • You regularly do at least 150 minutes of moderate exercise or 75 minutes of hard exercise each week.
  • You have chronic bronchitis, COPD or emphysema (long-term lung diseases), or high blood pressure in the lungs.
  • You have diabetes, heart failure, narrowed leg or heart arteries, stroke, kidney disease, or high blood pressure caused by another condition. You have poor blood flow in your veins or have had a deep vein blood clot in the last 6 months.
  • You have had cancer in the last 5 years, or your body mass index (BMI, a weight-to-height measure) is above 39.
  • You currently smoke or vape, or you work evening shifts.
  • You have an uncontrolled thyroid condition, or had anemia (too few healthy red blood cells) within 3 months of joining.
  • You have Parkinson’s disease or dementia, or have fallen at least twice in the last year.
  • You have unstable angina (new or worsening heart-related chest pain), a sudden lung blood clot or damage from blocked lung blood flow, sudden inflammation of the heart or its lining, or a sudden tear in the wall of the body’s main artery.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Systolic BP equal to or greater than 130 mmHg without BP medication or greater than 120 mmHg with medication and diastolic blood pressure equal to and greater than 80 mmHg * 55-80 years old * Post-menopausal female * Able to walk without assistance Exclusion Criteria: * Habitually physically active defined as 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic physical activity per week * Overt pulmonary disease/condition as follows: chronic bronchitis, chronic obstructive pulmonary disease, emphysema, or pulmonary hypertension * Cardiometabolic disease/condition as follows: diabetes, heart failure, peripheral arterial disease, stroke, coronary artery disease, renal disease, secondary hypertension, chronic venous insufficiency or deep vein thrombosis within last 6 months * Cancer within last 5 years * Body mass index \>39 kg/m2 * Current smoking or vape * Evening shift work * uncontrolled thyroid disorder * 2 or more falls in the last year * Anemia within 3 months of enrollment * Parkinson's disease * Dementia * Unstable angina * Acute pulmonary embolus or infarction * Acute myocarditis or pericarditis * Acute aortic dissection

Study sites (1)

MI