Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 18 Years to 70 Years
- Sex
- All sexes
- Healthy volunteers
- Accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
- Procedures mentioned: Biopsies
Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.
Show the study's own words
- "Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss."
- "After 12 weeks, this will be followed by the same testing and biopsies that were completed before the intervention."
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
In plain language
This study tests how weight loss changes signals from fat between muscles in adults with obesity. Researchers want to learn how these signals cause swelling and make muscles respond less well to insulin, a hormone that controls blood sugar. Participants follow a 12-week weight-loss diet and have tests and small samples of thigh muscle taken before and after.
The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation, and how these same molecules are diminished after weight loss. Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss. After 12 weeks, this will be followed by the same testing and biopsies that were completed before the intervention. Researchers will then compare outcomes of individuals who lost weight to individuals who did not lose weight.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Who can join
- Generally healthy men and women ages 18–70.
- Body mass index (BMI), a measure based on height and weight, between 30 and 40.
- Exercise less than 1 hour per week.
- Women may join before or after menopause, when monthly periods end.
Who can't join
- Type 1 or type 2 diabetes.
- Thyroid disease, which affects a gland in the neck.
- A history of lung disease.
- Currently using nicotine.
- Severe problems with fat levels in the blood.
- Taking hormone replacement drugs, blood thinners, or thiazolidinediones, a type of diabetes drug.
- Currently going through menopause or the changes leading up to it.
- Pregnant, breastfeeding, or have a history of polycystic ovary syndrome (PCOS), a hormone condition.
Simplified for readability. The official criteria below are what the study team uses.
Official eligibility criteria
Inclusion Criteria: * Generally healthy men and women aged 18-70 * BMI between 30-40 * Less than 1 hour of exercise per week * Women: 1. may be pre or post menopausal Exclusion Criteria: * Type 1 or Type 2 diabetes * Thyroid disease * History of lung disease * Active use of nicotine * Severe plasma lipid disorders * Taking hormone replacement drugs, blood thinners, or thiazoladinediones * Women: 1. Currently going through menopause or peri-menopause 2. Pregnant or breastfeeding 3. History of Polycystic Ovary Syndrome
Study sites (1)
CO
- University of Colorado Anschutz · Aurora, CO 80045Bryan Bergman, PhD · Study contactBryan Bergman, PhD · Principal investigatorMore trials in Aurora