ADAPT Study: Assessing Diet, Appetite and Physiology Throughout Weight Loss Study)
Physiological Changes Underlying the Weight Loss Plateau in Human
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 18 Years to 60 Years
- Sex
- All sexes
- Healthy volunteers
- Accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
- Procedures mentioned: Blood draws, MRI scans, X-rays, Biopsies, Questionnaires
Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.
Show the study's own words
- "Study Visit activities include questionnaires, blood draws, brain MRIs, body measurement and dual energy x-ray absorptiometry (DXA) scan for body composition measurement, a breathing test, and biopsies of muscle and fat tissue."
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
In plain language
This study looks at changes in how the body uses energy and how the brain works when weight loss stops, even when people keep trying. It is for people with obesity who can attend study classes and visits.
Behavioral weight loss programs for obesity can result in weight loss and health benefits. However, behavioral weight loss often stops despite efforts to continue losing weight, this can be called an involuntarily weight loss plateau. This study investigates changes in metabolism and/or the brain that contribute to the occurrence of an involuntary weight loss plateau.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Who can join
- Have a BMI of 30 to 50. BMI is a measure of weight compared with height.
- Be able to attend study classes, visits, and tests.
- Live independently and have a place to prepare food.
Who can't join
- Currently smoke, regularly use nicotine products or cannabis, or use drugs. Heavy drinking also rules you out: 2 or more drinks a day for women or 3 or more for men.
- Have known problems with thinking or memory, a past stroke, or type 2 diabetes, including an A1c blood sugar test result of 6.5% or higher.
- Have a health condition or lab result that limits participation, or any condition the study team and lead researchers agree makes participation unsafe.
- Are pregnant, gave birth after a full-term pregnancy within the past 6 months, or are breastfeeding.
- Take medicines that strongly affect appetite, such as weight loss drugs, certain mental health medicines, or stimulants; or regularly take blood thinners.
- Have had weight loss surgery or an eating disorder; are in a formal weight loss program; have ever joined a weight loss research study; or lost more than 10% of your weight in the past year.
- Weigh more than 330 pounds, or cannot have an MRI scan, such as because of metal in your body or fear of enclosed spaces.
- Cannot or will not eat the study foods, including because of an allergy or intolerance; or lack a phone that works with the activity tracker, access to video calls, or other needed technology.
Simplified for readability. The official criteria below are what the study team uses.
Official eligibility criteria
Inclusion Criteria: * BMI 30.0 - 50.0 kg/m2 * Able to attend study intervention classes and study visits/assessments * Independently living with access to food preparation facilities Exclusion Criteria: * Current smoker or regular use of nicotine containing products and/or cannabis * Heavy alcohol use (≥2 drinks/d for females, ≥3 drinks/d for males) or drug use * Known cognitive impairments or h/o stroke * Type 2 diabetes (known diagnosis or by screening A1c (≥6.5%)) * Medical conditions (chronic diseases, cancer, MS) or labs limiting ability to participate * Females: currently pregnant (or 6-months postpartum of full-term pregnancy) and/or current breastfeeding * Use of medications with significant effects on appetite (e.g., weight loss medications, atypical antipsychotics, stimulants) and/or chronic use of anticoagulants * History of bariatric surgery * History of eating disorder * Current participation in a formal weight loss program * Prior or current participation in a research study involving weight loss * Weight-reduced by \>10% within past year * Weight \> 330 pounds (MRI limit) * Allergy or intolerance to or unwillingness to consume study foods provided at visit * MRI contraindication (e.g., implanted metal, claustrophobia) * Do not have a phone compatible with activity tracker or access to videoconferencing platform that will be used for the dietary intervention or other appropriate technology needed to complete study procedures * Any condition(s) found by the study team and confirmed with the PI(s) that make it unsafe to participate
Study sites (2)
WA
- Fred Hutch Cancer Center · Seattle, WA 98109Diana Lowry · Study contact · dlowry@fredhutch.orgMore trials in Seattle
- University of Washington - South Lake Union · Seattle, WA 98109Mary Webb · Study contact · uwadaptstudy@uw.eduMore trials in Seattle