RightFit
RecruitingPhase 2 / Phase 3

Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
21 Years to 55 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether computer-based training improves thinking skills and brain responses in people seeking care for anxiety, depression, or stress after trauma. People are assigned by chance to the training or to similar computer exercises expected to help less. Researchers compare thinking skills and brain responses before and after the program.

The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program that is designed as a cognitive training intervention and Group 2 will receive a similar computer-based exercise that researchers think will be less effective in training thinking skills (also known as a control or sham condition). Participants will be compared on cognitive performance and brain response during cognitive tasks from baseline to post-treatment.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Age 21 to 55.
  • Fluent in English.
  • Diagnosed with a mood, anxiety, or trauma-related stress disorder.
  • Repeated negative thoughts that reach a level of clinical concern.
  • Getting care without staying in a hospital.
  • If taking an SSRI, a type of antidepressant, medication use must have been stable for 6 weeks.

Who can't join

  • Diagnosed in the past year with a severe alcohol use disorder or a moderate or severe substance use disorder.
  • Ever had bipolar I disorder or a psychotic disorder, which can affect a person's sense of reality.
  • At risk of suicide and needing immediate care.
  • A disorder affecting brain development or causing brain decline, a past moderate or severe brain injury, or another known brain or nerve condition.
  • Problems with senses, such as sight or hearing, that prevent doing the tasks.
  • A condition that makes an MRI brain scan unsafe, such as metal in the body.
  • Currently pregnant.
  • Currently getting talk therapy or other psychosocial treatment, or taking mental health medicines other than SSRIs.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * age 21-55 * fluent in English * diagnosis of mood, anxiety, or traumatic stress disorder * clinically elevated repetitive negative thinking * outpatient status * 6-week stability if taking selective serotonin reuptake inhibitor (SSRI) medications Exclusion Criteria: * past year diagnosis of severe alcohol or moderate or greater substance use disorder * lifetime history of psychotic or bipolar I disorder * acute suicidality necessitating immediate clinical intervention * neurodegenerative or neurodevelopmental disorders * history of moderate or severe traumatic brain injury or other known neurological condition * sensory deficits that would preclude completing tasks * conditions unsafe for completing MRI scanning (e.g., metal in body) * current pregnancy * currently receiving psychosocial treatment * currently receiving psychiatric pharmacotherapy, except SSRIs

Study sites (1)

CA