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Using TMS to Understand Neural Processes of Social Motivation

Personalized Neuromodulation Targeting Dysregulated Motivational Responses Underlying Social Avoidance Behavior

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
25 Years to 50 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Visits mentioned: 4 visits
  • Procedures mentioned: Questionnaires, Interviews, MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Participant includes four study visits each that range from 1.5 - 3.0 hours in duration over approximately a one month period."
  • "The first study visit involves answering survey questions, a clinical interview, and computer tasks."
  • "The second study visit involves a magnetic resonance imaging (MRI) scan, computer tasks, and a brief TMS protocol."
  • "The second and third study visits involve a full session of TMS followed by an MRI scan and computer tasks."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

The purpose of this study is to use transcranial magnetic stimulation (TMS) to better understand the neural circuits associated with social motivation. Participant includes four study visits each that range from 1.5 - 3.0 hours in duration over approximately a one month period. The first study visit involves answering survey questions, a clinical interview, and computer tasks. The second study visit involves a magnetic resonance imaging (MRI) scan, computer tasks, and a brief TMS protocol. The second and third study visits involve a full session of TMS followed by an MRI scan and computer tasks. Adults in the Auburn/Opelika area and surrounding areas who avoid social situations, experience symptoms of depression or social anxiety, and are between 25 years old and 50 years old are eligible to participate.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: * A diagnosis of Major Depressive Disorder OR a diagnosis of Social Anxiety Disorder (assessed/confirmed at screening visit). * Scoring above clinical threshold on a measure of social avoidant behavior (assessed/confirmed at phone screen). Exclusion Criteria: * Unstable psychotropic medication regimen (i.e., changes in psychotropic medication or dosage in past 3 months). * Current or lifetime diagnosis of Bipolar Disorder. * A diagnosis of substance use disorder within past 12 months. * A diagnosis of psychotic-spectrum disorder such as Schizophrenia. * Pregnancy or probable pregnancy. * Medical illness or medical treatment that would preclude or inhibit study participation. * Neurological disorder associated with brain damage. * History of seizures or head trauma with loss of consciousness \> 5 minutes. * Family history of epilepsy or personal epilepsy/seizures * Ferromagnetic implants or ferrmagnetic objects within body (e.g., pacemaker).

Study sites (1)

AL